Recombinant Human TNFSF4 Protein, His-tagged
Cat.No. : | TNFSF4-142H |
Product Overview : | Recombinant Human TNFSF4 Protein with His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | OX40 (TNFRSF4, CD134) is a member of the tumor necrosis factor (TNF) receptor superfamily that regulates T cell activity and immune responses. The OX40 protein contains four cysteine rich domains, a transmembrane domain, and a cytoplasmic tail containing a QEE motif. OX40 is primarily expressed on activated CD4+ and CD8+ T-cells, while the OX40 ligand (OX40L, TNFSF4, CD252) is predominantly expressed on activated antigen presenting cells. The engagement of OX40 with OX40L leads to the recruitment of TNF receptor-associated factors (TRAFs) and results in the formation of a TCR-independent signaling complex. One component of this complex, PKCθ, activates the NF-κB pathway. OX40 signaling through Akt can also enhance TCR signaling directly. Research studies indicate that the OX40L-OX40 pathway is associated with inflammation and autoimmune diseases. Additional research studies show that OX40 agonists augment anti-tumor immunity in several cancer types. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Molecular Mass : | ~15 kDa |
AA Sequence : | MERVQPLEENVGNAARPRFERNKLL LVASVIQGLGLLLCFTYICLHFSAL QVSHRYPRIQSIKVQFTEYKKEKGF ILTSQKEDEIMKVQNNSVIINCDGF YLISLKGYFSQEVNISLHYQKDEEP LFQLKKVRSVNSLMVASLTYKDKVY LNVTTDNTSLDDFHVNGGELILIHQ NPGEFCVL |
Purity : | Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
Notes : | For research use only, not for use in diagnostic procedure. |
Storage : | Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
Storage Buffer : | PBS, 4M Urea, pH7.4 |
Gene Name : | TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 [ Homo sapiens (human) ] |
Official Symbol : | TNFSF4 |
Synonyms : | TNFSF4; tumor necrosis factor (ligand) superfamily, member 4; tax transcriptionally activated glycoprotein 1, 34kD , TXGP1; tumor necrosis factor ligand superfamily member 4; CD252; gp34; OX 40L; OX40L; CD134 ligand; glycoprotein Gp34; OX40 antigen ligand; TAX transcriptionally-activated glycoprotein 1; tax-transcriptionally activated glycoprotein 1 (34kD); GP34; OX4OL; TXGP1; CD134L; OX-40L; |
Gene ID : | 7292 |
mRNA Refseq : | NM_003326 |
Protein Refseq : | NP_003317 |
MIM : | 603594 |
UniProt ID : | P23510 |
Products Types
◆ Recombinant Protein | ||
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TNFSF4-5861R | Recombinant Rat TNFSF4 Protein, His (Fc)-Avi-tagged | +Inquiry |
TNFSF4-2259H | Recombinant Human TNFSF4 Protein, MYC/DDK-tagged | +Inquiry |
TNFSF4-688H | Recombinant Human TNFSF4 Protein | +Inquiry |
TNFSF4-689H | Recombinant Human TNFSF4 Protein, Fc-tagged | +Inquiry |
◆ Lysates | ||
TNFSF4-857CCL | Recombinant Cynomolgus TNFSF4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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