Recombinant Human TNIK Protein (D11-G314), His tagged

• Cat.No.: TNIK-1072H
• Product Overview: Recombinant Human 8His-TEV-TNIK(D11-G314) Protein was expressed in Insect cell.

Specification

• Description: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.
• Source: Insect cell
• Species: Human
• Tag: His
• Form: Liquid
• Protein Length: D11-G314
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: TNIK TRAF2 and NCK interacting kinase [ Homo sapiens (human) ]
• Official Symbol: TNIK
• Synonyms: TNIK; TRAF2 and NCK interacting kinase; TRAF2 and NCK-interacting protein kinase; KIAA0551
• Gene ID: 23043
• mRNA Refseq: NM_001161560
• Protein Refseq: NP_001155032
• MIM: 610005
• UniProt ID: Q9UKE5