| Description : |
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19. |
| Source : |
E. coli |
| Species : |
Human |
| Form : |
Solution |
| Molecular Mass : |
24 kDa |
| Protein Length : |
210 |
| AA Sequence : |
MADGSSDAAREPRPAPAPIRRRSSN YRAYATEPHAKKKSKISASRKLQLK TLLLQIAKQELEREAEERRGEKGRA LSTRCQPLELAGLGFAELQDLCRQL HARVDKVDEERYDIEAKVTKNITEI ADLTQKIFDLRGKFKRPTLRRVRIS ADAMMQALLGARAKESLDLRAHLKQ VKKEDTEKENREVGDWRKNIDALSG MEGRKKKFES |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
Tris (pH 8). Sterile-filtered colorless solution. |
| Reconstitution : |
Solution for appropriate storage temperature |
