Recombinant Human TPH1 protein(Ile2-Ile444), His-tagged

• Cat.No.: TPH1-1172H
• Product Overview: Recombinant Human TPH1 (P17752-1) (Ile 2-Ile 444) was expressed in E. coli, with a polyhistide tag at the N-terminus.

Specification

• Source: E. coli
• Species: Human
• Tag: N-His
• Protein length: Ile2-Ile444
• Form: Lyophilized from sterile 20mM Tris, 200mM NaCl, 10% glycerol, pH 8.0. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Molecular Mass: The recombinant human TPH1 consisting of 458 amino acids and has a calculated molecular mass of 52.7 kDa. It migrates as an approximately 48 kDa band in SDS-PAGE under reducing conditions.
• Purity: > 95 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: TPH1 tryptophan hydroxylase 1 [ Homo sapiens ]
• Official Symbol: TPH1
• Synonyms: TPH1; tryptophan hydroxylase 1; TPH, TPRH, tryptophan hydroxylase (tryptophan 5 monooxygenase); tryptophan 5-hydroxylase 1; tryptophan 5 monooxygenase; L-tryptophan hydroxylase; tryptophan 5-monooxygenase 1; indoleacetic acid-5-hydroxylase; tryptophan hydroxylase (tryptophan 5-monooxygenase); TPRH; TRPH; MGC119994
• Gene ID: 7166
• mRNA Refseq: NM_004179
• Protein Refseq: NP_004170
• MIM: 191060
• UniProt ID: P17752

Reviews

05/13/2022

the TPH1 protein stands out for its exceptional quality and its ability to fulfill my experimental requirements.

04/14/2016

Its compatibility with various methodologies further enhances its value as a research tool, making it a go-to choice for investigating TPH1 protein function and molecular interactions.

02/13/2016

The versatility of the TPH1 protein extends beyond these applications, enabling its use in a wide range of experimental techniques.

Q&As

How is TPH1 protein measured in clinical practice?

TPH1 protein can be measured in clinical practice using techniques such as enzyme-linked immunosorbent assay (ELISA) or immunohistochemistry.

How does TPH1 protein contribute to the regulation of circadian rhythm?

TPH1 protein contributes to the regulation of circadian rhythm by influencing the synthesis of serotonin, which in turn affects mood, sleep, and behavior.

How is TPH1 protein involved in the gut-brain axis?

TPH1 protein is involved in the gut-brain axis by influencing serotonin production in the gastrointestinal tract, which in turn can affect mood and behavior.

What are the implications of TPH1 polymorphisms in clinical settings?

TPH1 polymorphisms have implications in clinical settings as they are associated with variations in serotonin levels and susceptibility to psychiatric disorders.

What are the potential clinical applications of TPH1 inhibitors?

TPH1 inhibitors have potential clinical applications in the treatment of psychiatric disorders, gastrointestinal disorders, and migraine.