Recombinant Human TPMT Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | TPMT-5121H |
Product Overview : | TPMT MS Standard C13 and N15-labeled recombinant protein (NP_000358) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 28.2 kDa |
AA Sequence : | MDGTRTSLDIEEYSDTEVQKNQVLT LEEWQDKWVNGKTAFHQEQGHQLLK KHLDTFLKGKSGLRVFFPLCGKAVE MKWFADRGHSVVGVEISELGIQEFF TEQNLSYSEEPITEIPGTKVFKSSS GNISLYCCSIFDLPRTNIGKFDMIW DRGALVAINPGDRKCYADTMFSLLG KKFQYLLCVLSYDPTKHPGPPFYVP HAEIERLFGKICNIRCLEKVDAFEE RHKSWGIDCLFEKLYLLTEKTRTRP LEQKLISEEDLAANDILDYKDDDDK V |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | TPMT thiopurine S-methyltransferase [ Homo sapiens (human) ] |
Official Symbol : | TPMT |
Synonyms : | TPMT; thiopurine S-methyltransferase; S-adenosyl-L-methionine:thiopurine S-methyltransferase; |
Gene ID : | 7172 |
mRNA Refseq : | NM_000367 |
Protein Refseq : | NP_000358 |
MIM : | 187680 |
UniProt ID : | P51580 |
Products Types
◆ Recombinant Protein | ||
TPMT-9540M | Recombinant Mouse TPMT Protein, His (Fc)-Avi-tagged | +Inquiry |
Tpmt-6602M | Recombinant Mouse Tpmt Protein, Myc/DDK-tagged | +Inquiry |
TPMT-3372H | Recombinant Human TPMT, GST-tagged | +Inquiry |
TPMT-8091H | Recombinant Human TPMT protein, His-tagged | +Inquiry |
TPMT-3612H | Recombinant Human TPMT protein, GST-tagged | +Inquiry |
◆ Lysates | ||
TPMT-841HCL | Recombinant Human TPMT 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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