Recombinant Human TRAV21 Protein, His-tagged
Cat.No. : | TRAV21-69H |
Product Overview : | Recombinant Human TRAV21 Protein, fused to His-tag, was expressed in E. coli. |
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Description : | T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Supplied as a 0.2 μm filtered solution in PBS, pH7.4. |
Molecular Mass : | ~38.2 kDa |
AA Sequence : | MGKQEVTQIPAALSVPEGENLVLNC SFTDSAIYNLQWFRQDPGKGLTSLL LITPWQREQTSGRLNASLDKSSGRS TLYIAASQPGDSATYLCAVRPLLDG TYIPTFGRGTSLIVHPYIQNPDPAV YQLRDSKSSDKSVCLFTDFDSQTNV SQSKDSDVYITDKGGGGSGGGGSGG GGSGVTQTPKFQVLKTGQSMTLQCA QDMNHEYMSWYRQDPGMGLRLIHYS VAIQTTDQGEVPNGYNVSRSTIEDF PLRLLSAAPSQTSVYFCASSYLGNT GELFFGEGSRLTVLEDLKNVFPPEV AVFEPSEAEISHTQKATLVCLATGF YPDHVELSWWVNGKEVHSGVHHHHH H |
Purity : | >90% |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Concentration : | 1.6 mg/mL |
Gene Name : | TRAV21 T cell receptor alpha variable 21 [ Homo sapiens (human) ] |
Official Symbol : | TRAV21 |
Synonyms : | TCRAV21S1; TCRAV23S1 |
Gene ID : | 28662 |
UniProt ID : | A0A0B4J279 |
Products Types
◆ Recombinant Protein | ||
TRAV21-03H | Recombinant Human TRAV21 Protein, His-tagged | +Inquiry |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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