| Description : |
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
38.8 kDa |
| AA Sequence : |
MNIHRSTPITIARYGRSRNKTQDFE ELSSIRSAEPSQSFSPNLGSPSPPE TPNLSHCVSCIGKYLLLEPLEGDHV FRAVHLHSGEELVCKVFDISCYQES LAPCFCLSAHSNINQITEIILGETK AYVFFERSYGDMHSFVRTCKKLREE EAARLFYQIASAVAHCHDGGLVLRD LKLRKFIFKDEERTRVKLESLEDAY ILRGDDDSLSDKHGCPAYVSPEILN TSGSYSGKAADVWSLGVMLYTMLVG RYPFHDIEPSSLFSKIRRGQFNIPE TLSPKAKCLIRSILRREPSERLTSQ EILDHPWFSTDFSVSNSAYGAKEVS DQLVPDVNMEENLDPFFNTRTRPLE QKLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
