| Description : |
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
97.4 kDa |
| AA Sequence : |
MEGSPSLRRMTVMREKGRRQAVRGP AFMFNDRGTSLTAEEERFLDAAEYG NIPVVRKMLEESKTLNVNCVDYMGQ NALQLAVGNEHLEVTELLLKKENLA RIGDALLLAISKGYVRIVEAILNHP GFAASKRLTLSPCEQELQDDDFYAY DEDGTRFSPDITPIILAAHCQKYEV VHMLLMKGARIERPHDYFCKCGDCM EKQRHDSFSHSRSRINAYKGLASPA YLSLSSEDPVLTALELSNELAKLAN IEKEFKNDYRKLSMQCKDFVVGVLD LCRDSEEVEAILNGDLESAEPLEVH RHKASLSRVKLAIKYEVKKFVAHPN CQQQLLTIWYENLSGLREQTIAIKC LVVLVVALGLPFLAIGYWIAPCSRL GKILRSPFMKFVAHAASFIIFLGLL VFNASDRFEGITTLPNITVTDYPKQ IFRVKTTQFTWTEMLIMVWVLGMMW SECKELWLEGPREYILQLWNVLDFG MLSIFIAAFTARFLAFLQATKAQQY VDSYVQESDLSEVTLPPEIQYFTYA RDKWLPSDPQIISEGLYAIAVVLSF SRIAYILPANESFGPLQISLGRTVK DIFKFMVLFIMVFFAFMIGMFILYS YYLGAKVNAAFTTVEESFKTLFWSI FGLSEVTSVVLKYDHKFIENIGYVL YGIYNVTMVVVLLNMLIAMINSSYQ EIEDDSDVEWKFARSKLWLSYFDDG KTLPPPFSLVPSPKSFVYFIMRIVN FPKCRRRRLQKDIEMGMGNSKSRLN LFTQSNSRVFESHSFNSILNQPTRY QQIMKRLIKRYVLKAQVDKENDEVN EGELKEIKQDISSLRYELLEDKSQA TEELAILIHKLSEKLNPSMLRCETR TRPLEQKLISEEDLAANDILDYKDD DDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
