| Description : |
This gene encodes a zinc-finger transcription factor that regulates smooth muscle cell differentiation in the developing urinary tract. Consistent with this role, mice in which this gene has been inactivated exhibit abnormal gene expression in urinary tract smooth muscle cell precursors and kidney defects including hydronephrosis. The encoded transcription factor comprises a gene silencing complex that inhibits caspase expression. Reduced expression of this gene and consequent caspase upregulation may be correlated with progression of Alzheimer's disease in human patients. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
118.4 kDa |
| AA Sequence : |
MPRRKQQAPRRAAAYVSEELKAAAL VDEGLDPEEHTADGEPSAKYMCPEK ELARACPSYQNSPAAEFSCHEMDSE SHISETSDRMADFESGSIKNEEETK EVTVPLEDTTVSDSLEQMKAVYNNF LSNSYWSNLNLNLHQPSSEKNNGSS SSSSSSSSSCGSGSFDWHQSAMAKT LQQVSQSRMLPEPSLFSTVQLYRQS SKLYGSIFTGASKFRCKDCSAAYDT LVELTVHMNETGHYRDDNHETDNNN PKRWSKPRKRSLLEMEGKEDAQKVL KCMYCGHSFESLQDLSVHMIKTKHY QKVPLKEPVTPVAAKIIPATRKKAS LELELPSSPDSTGGTPKATISDTND ALQKNSNPYITPNNRYGHQNGASYA WHFEARKSQILKCMECGSSHDTLQE LTAHMMVTGHFIKVTNSAMKKGKPI VETPVTPTITTLLDEKVQSVPLAAT TFTSPSNTPASISPKLNVEVKKEVD KEKAVTDEKPKQKDKPGEEEEKCDI SSKYHYLTENDLEESPKGGLDILKS LENTVTSAINKAQNGTPSWGGYPSI HAAYQLPNMMKLSLGSSGKSTPLKP MFGNSEIVSPTKNQTLVSPPSSQTS PMPKTNFHAMEELVKKVTEKVAKVE EKMKEPDGKLSPPKRATPSPCSSEV GEPIKMEASSDGGFRSQENSPSPPR DGCKDGSPLAEPVENGKELVKPLAS SLSGSTAIITDHPPEQPFVNPLSAL QSVMNIHLGKAAKPSLPALDPMSML FKMSNSLAEKAAVATPPPLQSKKAD HLDRYFYHVNNDQPIDLTKGKSDKG CSLGSVLLSPTSTAPATSSSTVTTA KTSAVVSFMSNSPLRENALSDISDM LKNLTESHTSKSSTPSSISEKSDID GATLEEAEESTPAQKRKGRQSNWNP QHLLILQAQFAASLRQTSEGKYIMS DLSPQERMHISRFTGLSMTTISHWL ANVKYQLRRTGGTKFLKNLDTGHPV FFCNDCASQIRTPSTYISHLESHLG FRLRDLSKLSTEQINSQIAQTKSPS EKMVTSSPEEDLGTSYQCKLCNRTF ASKHAVKLHLSKTHGKSPEDHLLYV SELEKQTRTRPLEQKLISEEDLAAN DILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
