Recombinant Human TXNRD2 Protein
Cat.No. : | TXNRD2-22H |
Product Overview : | Recombinant Human Thioredoxin Reductase 2 (Non-tagged; No signal peptide; 488 residues) |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms, including a few localized in the cytosol and some lacking the C-terminal Sec residue, have been found for this gene. |
Species : | Human |
Tag : | Tag Free |
Purity : | ≥ 95% as judged by gel analysis |
Unit Definition : | 1 U of enzyme reduces 1 μmol DTNB per min in 0.5 mL standard DTNB assay containing 2.5 mM DTNB and 0.3 mM NADPH in TE buffer (50 mM Tris-HCl, 2 mM EDTA, pH 7.5) |
Applications : | DTNB assay; Insulin-coupled Thioredoxin assay; Inhibitor screening; etc. |
Notes : | Centrifuge the tube briefly before opening the lid |
Storage : | Store at -20 centigrade upon delivery. |
Concentration : | 1 mg/mL |
Storage Buffer : | TE buffer with 50% glycerol. |
Shipping : | Shipped in cold pack by courier service. |
Gene Name : | TXNRD2 thioredoxin reductase 2 [ Homo sapiens (human) ] |
Official Symbol : | TXNRD2 |
Synonyms : | TXNRD2; thioredoxin reductase 2; TR; TR3; SELZ; GCCD5; TRXR2; TR-BETA; thioredoxin reductase 2, mitochondrial; selenoprotein Z; thioredoxin reductase 3; thioredoxin reductase TR3; thioredoxin reductase beta; EC 1.8.1.9 |
Gene ID : | 10587 |
mRNA Refseq : | NM_006440 |
Protein Refseq : | NP_006431 |
MIM : | 606448 |
UniProt ID : | Q9NNW7 |
Products Types
◆ Recombinant Protein | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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