Recombinant Human TYK2, His-tagged
Cat.No. : | TYK2-702H |
Product Overview : | Recombinant Human TYK2(a.a. 871-1187), fused with N-terminal His-tag, was expressed in a Baculovirus-infected Sf9 cell expression system. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. |
Source : | Baculovirus-infected Sf9 cell |
Species : | Human |
Tag : | His |
Form : | 45 mM Tris, pH 8, 125 mM NaCl, 2.4 mM KCl, 0.045% Tween-20, 100 mM imidazole and 10% glycerol. |
Molecular Mass : | 38 kDa |
Applications : | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Quality Control Test : | Assay conditions: Assay was done in Kinase buffer containing 0.2 mM DTT using Poly-(Glu4:Tyr)-biotin substrate (0.2 mg/ml) and 20 mM ATP. Reaction was done at 30°C for 30 minutes. Amount of ATP transferred was calculated using Kinase-Glo reagent (Promega). |
Stability : | >6 months at –80°C |
Gene Name : | TYK2 tyrosine kinase 2 [ Homo sapiens (human) ] |
Official Symbol : | TYK2 |
Synonyms : | TYK2; JTK1; tyrosine kinase 2; non-receptor tyrosine-protein kinase TYK2; NP_003322.3; EC 2.7.10.2 |
Gene ID : | 7297 |
mRNA Refseq : | NM_003331 |
Protein Refseq : | NP_003322 |
MIM : | 176941 |
UniProt ID : | P29597 |
Chromosome Location : | 19p13.2 |
Pathway : | Cytokine Signaling in Immune system; Epstein-Barr virus infection; Herpes simplex infection |
Function : | ATP binding; growth hormone receptor binding; non-membrane spanning protein tyrosine kinase activity |
Products Types
◆ Lysates | ||
TYK2-1867HCL | Recombinant Human TYK2 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1635 | TYK2 Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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