Recombinant Human UBA3, GST-tagged
Cat.No. : | UBA3-254H |
Product Overview : | Recombinant full-length human UBA3 (UBE1C) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Description : | UBA3 (also known as UBE1C) or ubiquitin-like modifier activating enzyme 3 is a member of the E1 ubiquitin-activating enzyme family. UBA3 associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. The mechanism of NEDD8 activation by APPBP1-UBA3 shows a high degree of conservation with ubiquitin activation by UBA1. The NEDD8-activating enzyme, or NAE, composed of NAE1 and UBA3 subunits, is an essential component for the treatment of cancer disease. |
Source : | Sf9 insect cells using baculovirus |
Species : | Human |
Tag : | GST |
Form : | Recombinant protein stored in 50mM Tis-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Molecular Mass : | ~73 kDa |
Purity : | >95% by densitometry |
Applications : | Western Blot |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1 μg/μl |
Gene Name : | UBA3 ubiquitin-like modifier activating enzyme 3 [ Homo sapiens ] |
Official Symbol : | UBA3 |
Synonyms : | UBA3; ubiquitin-like modifier activating enzyme 3; UBE1C, ubiquitin activating enzyme E1C (homologous to yeast UBA3) , ubiquitin activating enzyme E1C (UBA3 homolog, yeast); NEDD8-activating enzyme E1 catalytic subunit; hUba3; ubiquitin activating enzyme E1 homolog (yeast); NEDD8-activating enzyme E1C; Nedd8-activating enzyme hUba3; ubiquitin-activating enzyme 3; ubiquitin-like modifier-activating enzyme 3; UBA3, ubiquitin-activating enzyme E1 homolog; ubiquitin-activating enzyme E1C (UBA3 homolog, yeast); ubiquitin-activating enzyme E1C (homologous to yeast UBA3); UBE1C; hUBA3; MGC22384; DKFZp566J164; |
Gene ID : | 9039 |
mRNA Refseq : | NM_003968 |
Protein Refseq : | NP_003959 |
MIM : | 603172 |
UniProt ID : | Q8TBC4 |
Chromosome Location : | 3p24.3-p13 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Coregulation of Androgen receptor activity, organism-specific biosystem; Immune System, organism-specific biosystem; |
Function : | ATP binding; NEDD8 activating enzyme activity; acid-amino acid ligase activity; ligase activity; nucleotide binding; protein binding; protein heterodimerization activity; |
Products Types
◆ Recombinant Protein | ||
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UBA3-6042R | Recombinant Rat UBA3 Protein, His (Fc)-Avi-tagged | +Inquiry |
UBA3-4860R | Recombinant Rhesus Macaque UBA3 Protein, His (Fc)-Avi-tagged | +Inquiry |
UBA3-522H | Recombinant Human UBA3 Protein, His-tagged | +Inquiry |
UBA3-811C | Recombinant Cynomolgus Monkey UBA3 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
UBA3-604HCL | Recombinant Human UBA3 293 Cell Lysate | +Inquiry |
UBA3-605HCL | Recombinant Human UBA3 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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