Recombinant Human UBE2D2, His-tagged

• Cat.No.: UBE2D2-37H
• Product Overview: Recombinant Human UBE2D2 produced inE. coliwas fused to a his tag.

Specification

• Cat. No.: UBE2D2-37H
• Description: UbcH5b is highly homologous to the S. cerevisiae UbC4/5 family of E2 enzymes, demonstrated to be essential for degradation of regulatory and abnormal proteins. UbcH5b, together with UbcH5a and UbcH5c, are the most active class of E2 enzymes in cell extracts and are associated with regulation of a number of transcription factors including p53.
• Source: E. coli.
• Purity: 95% (SDS-PAGE).
• Application: Useful forin vitro ubiquitinylation reactions. The His-tagged version of this enzyme is not susceptible to self-ubiquitinylation, which can occur with GST-tagged versions.
• Storage: -80°C.

Gene Information

• Gene Name: UBE2D2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) [ Homo sapiens ]
• Synonyms: UBE2D2; ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast); UBC4; PUBC1; UBC4/5; UBCH5B; E2(17)KB2; ubiquitin-conjugating enzyme E2 D2; ubiquitin-protein ligase D2; ubiquitin carrier protein D2; ubiquitin-conjugating enzyme E2(17)KB 2; ubiquitin-conjugating enzyme E2-17 kDa 2; ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5); EC 6.3.2.19; ubiquitin carrier protein
• Gene ID: 7322
• mRNA Refseq: NM_003339
• Protein Refseq: NP_003330
• MIM: 602962
• UniProt ID: P62837
• Chromosome Location: 5q31.2
• Pathway: Ubiquitin mediated proteolysis
• Function: ATP binding; ligase activity; nucleotide binding; protein binding; ubiquitin-protein ligase activity

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Q&As

How does UBE2D2 interact with other components of the ubiquitin-proteasome system?

UBE2D2 works in tandem with other ubiquitin-proteasome system components, orchestrating protein degradation.

How does UBE2D2 contribute to cellular protein degradation?

It facilitates the attachment of ubiquitin to target proteins, directing them to the proteasome for breakdown.

What role does UBE2D2 play in cell cycle regulation?

UBE2D2 plays a role in controlling the cell cycle by regulating the degradation of key cycle-related proteins.

What potential therapeutic applications arise from targeting UBE2D2 in diseases related to protein misfolding?

Targeting UBE2D2 could offer new treatments for conditions involving protein misfolding and aggregation.

What is the impact of altered UBE2D2 activity on disease development?

Altered UBE2D2 activity is linked with several diseases, including cancer and neurodegenerative disorders.

How do genetic variations in UBE2D2 affect cellular homeostasis?

Genetic mutations in UBE2D2 can disrupt protein turnover, affecting various cellular functions and stability.

What is the primary role of UBE2D2 in protein ubiquitination?

UBE2D2, a ubiquitin-conjugating enzyme, is vital for tagging proteins with ubiquitin, marking them for degradation.