Recombinant Human UBE2S Protein (N2-L222), Tag Free
Cat.No. : | UBE2S-0011H |
Product Overview : | Recombinant Human (GG)-UBE2S(N2-L222 end) Protein was expressed in Insect cell. |
- Specification
- Gene Information
- Related Products
Description : | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination. |
Source : | Insect cell |
Species : | Human |
Tag : | No tag |
Form : | Liquid |
Protein Length : | N2-L222 |
Endotoxin : | < 0.01 EU per μg of the protein |
Purity : | 90% |
Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 1 mM DTT, 5% glycerol. |
Shipping : | It is shipped out with blue ice. |
Gene Name : | UBE2S ubiquitin-conjugating enzyme E2S [ Homo sapiens (human) ] |
Official Symbol : | UBE2S |
Synonyms : | UBE2S; ubiquitin-conjugating enzyme E2S; ubiquitin-conjugating enzyme E2 S; E2 EPF; ubiquitin carrier protein; ubiquitin conjugating enzyme E2 24 kD; ubiquitin protein ligase; E2-EPF5; ubiquitin-protein ligase S; ubiquitin carrier protein S; ubiquitin-conjugating enzyme E2-EPF5; ubiquitin-conjugating enzyme E2-24 kD; ubiquitin-conjugating enzyme E2-24 kDa; EPF5; E2EPF; E2-EPF; |
Gene ID : | 27338 |
mRNA Refseq : | NM_014501 |
Protein Refseq : | NP_055316 |
MIM : | 610309 |
UniProt ID : | Q16763 |
Products Types
◆ Recombinant Protein | ||
Ube2s-6798M | Recombinant Mouse Ube2s Protein, Myc/DDK-tagged | +Inquiry |
UBE2S-9838M | Recombinant Mouse UBE2S Protein, His (Fc)-Avi-tagged | +Inquiry |
UBE2S-6060R | Recombinant Rat UBE2S Protein, His (Fc)-Avi-tagged | +Inquiry |
UBE2S-0012H | Recombinant Human UBE2S Protein (N2-L222), His/Strep tagged | +Inquiry |
UBE2S-4880R | Recombinant Rhesus Macaque UBE2S Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
UBE2S-562HCL | Recombinant Human UBE2S 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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