Recombinant Human UCK2 protein, T7-tagged

• Cat.No.: UCK2-145H
• Product Overview: Recombinant human UCK2 (261 aa) fused with T7 Tag at N-terminal was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: T7
• Form: 0.2 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose and DTT.
• AA Sequence: MASMTGGQQMGRGEFGSTSMAGDSE QTLQNHQQPNGGEPFLIGVSGGTAS GKSSVCAKIVQLLGQNEVDYRQKQV VILSQDSFYRVLTSEQKAKALKGQF NFDHPDAFDNELILKTLKEITEGKT VQIPVYDFVSHSRKEETVTVYPADV VLFEGILAFYSQEVRDLFQMKLFVD TDADTRLSRRVLRDISERGRDLEQI LSQYITFVKPAFEEFCLPTKKYADV IIPRGADNLVAINLIVQHIQDILNG GPSKRQTNGCLNGYTPSRKRQASES SSRPH
• Purity: >90% by SDS-PAGE
• Applications: 1. May be used for in vitro UCK2 mediated phosphorylation of uridine-cytidine regulation study with intracellular delivery of this protein.2. As soluble / native protein, may be used as enzymatic substrate protein for kinase and ubiquitin assay development.3. May be used for mapping UCK2 protein-protein interaction.4. May be used as antigen for specific antibody development.
• Storage: Keep at -80 centigrade for long term storage. Product is stable at 4 centigrade for at least 7 days.

Gene Information

• Gene Name: UCK2 uridine-cytidine kinase 2 [ Homo sapiens ]
• Official Symbol: UCK2
• Synonyms: UCK2; uridine-cytidine kinase 2; UMPK, uridine monophosphate kinase; uridine kinase; uridine monophosphokinase 2; cytidine monophosphokinase 2; uridine monophosphate kinase; testis-specific protein TSA903; UK; UMPK; TSA903; DKFZp686M04245
• Gene ID: 7371
• mRNA Refseq: NM_012474
• Protein Refseq: NP_036606
• MIM: 609329
• UniProt ID: Q9BZX2
• Chromosome Location: 1p32
• Pathway: Drug metabolism - other enzymes, organism-specific biosystem; Drug metabolism - other enzymes, conserved biosystem; Fluoropyrimidine Activity, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; Pyrimidine metabolism, organism-specific biosystem
• Function: ATP binding; kinase activity; nucleoside kinase activity; nucleotide binding; phosphotransferase activity, alcohol group as acceptor; transferase activity; uridine kinase activity

Reviews

08/24/2022

I highly endorse the utilization of the UCK2 Protein for researchers seeking a superior protein solution that not only meets their experimental needs but also benefits from the exceptional technical support provided by the manufacturer.

10/09/2021

Their expertise has proven instrumental in overcoming obstacles and has greatly contributed to the success of my research endeavors.

05/07/2020

Their team of experts has been extremely helpful in addressing any concerns or queries I encountered during my experiments.

Q&As

Can UCK2 protein levels in patient samples be measured for clinical assessment?

Yes, UCK2 protein levels can be quantified in patient samples using techniques such as immunohistochemistry and ELISA for clinical assessment.

Are there any genetic mutations associated with UCK2 protein that impact clinical outcomes?

Certain genetic mutations in the UCK2 gene have been linked to altered UCK2 protein function, which may impact clinical outcomes in certain diseases.

Does UCK2 protein have any role in neurological disorders?

Some studies have suggested a potential link between UCK2 protein and neurological disorders, although further research is needed to fully understand this association.

How is UCK2 protein involved in liver diseases?

UCK2 protein has been implicated in liver diseases, particularly in the context of nucleoside analog metabolism and liver cell function.

What role does UCK2 protein play in drug resistance in cancer?

UCK2 protein has been associated with drug resistance in cancer cells, particularly in the context of chemotherapy.