Recombinant Human UNC45B Protein, MYC/DDK-tagged, C13 and N15-labeled
Cat.No. : | UNC45B-096H |
Product Overview : | UNC45B MS Standard C13 and N15-labeled recombinant protein (NP_775259) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 103.6 kDa |
AA Sequence : | MAEVEAVQLKEEGNRHFQLQDYKAA TNSYSQALKLTKDKALLATLYRNRA ACGLKTESYIQAASDASRAIDINSS DIKALYRRCQALEHLGKLDQAFKDV QRCATLEPRNQNFQEMLRRLNTSIQ EKLRVQFSTDSRVQKMFEILLDENS EADKREKAANNLIVLGREEAGAEKI FQNNGVALLLQLLDTKKPELVLAAV RTLSGMCSGHQARATVILHAVRIDR ICSLMAVENEEMSLAVCNLLQAIID SLSGEDKREHRGKEEALVLDTKKDL KQITSHLLDMLVSKKVSGQGRDQAL NLLNKNVPRKDLAIHDNSRTIYVVD NGLRKILKVVGQVPDLPSCLPLTDN TRMLASILINKLYDDLRCDPERDHF RKICEEYITGKFDPQDMDKNLNAIQ TVSGILQGPFDLGNQLLGLKGVMEM MVALCGSERETDQLVAVEALIHAST KLSRATFIITNGVSLLKQIYKTTKN EKIKIRTLVGLCKLGSAGGTDYGLR QFAEGSTEKLAKQCRKWLCNMSIDT RTRRWAVEGLAYLTLDADVKDDFVQ DVPALQAMFELAKXXTSDKTILYSV ATTLVNCTNSYDVKEVIPELVQLAK FSKQHVPEEHPKDKKDFIDMRVKRL LKAGVISALACMVKADSAILTDQTK ELLARVFLALCDNPKDRGTIVAQGG GKALIPLALEGTDVGKVKAAHALAK IAAVSNPDIAFPGERVYEVVRPLVR LLDTQRDGLQNYEALLGLTNLSGRS DKLRQKIFKERALPDIENYMFENHD QLRQAATECMCNMVLHKEVQERFLA DGNDRLKLVVLLCGEDDDKVQNAAA GALAMLTAAHKKLCLKMTQVTTQWL EILQRLCLHDQLSVQHRGLVIAYNL LAADAELAKKLVESELLEILTVVGK QEPDEKKAEVVQTARECLIKCMDYG FIKPVSTRTRPLEQKLISEEDLAAN DILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | UNC45B unc-45 myosin chaperone B [ Homo sapiens (human) ] |
Official Symbol : | UNC45B |
Synonyms : | UNC45B; unc-45 myosin chaperone B; CMYA4; CTRCT43; SMUNC45; UNC-45B; UNC45; protein unc-45 homolog B; cardiomyopathy associated 4; striated muscle UNC45; unc-45 homolog B |
Gene ID : | 146862 |
mRNA Refseq : | NM_173167 |
Protein Refseq : | NP_775259 |
MIM : | 611220 |
UniProt ID : | Q8IWX7 |
Products Types
◆ Recombinant Protein | ||
UNC45B-2316H | Recombinant Human UNC45B Protein, His (Fc)-Avi-tagged | +Inquiry |
UNC45B-9914M | Recombinant Mouse UNC45B Protein, His (Fc)-Avi-tagged | +Inquiry |
Unc45b-6837M | Recombinant Mouse Unc45b Protein, Myc/DDK-tagged | +Inquiry |
UNC45B-30132H | Recombinant Human UNC45B protein, GST-tagged | +Inquiry |
UNC45B-9480Z | Recombinant Zebrafish UNC45B | +Inquiry |
◆ Lysates | ||
UNC45B-1886HCL | Recombinant Human UNC45B cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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