Recombinant Human V-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog

• Cat.No.: KRAS-1246H
• Product Overview: Recombinant humanKRAS containing 188 amino acids.

Specification

• Cat. No.: KRAS-1246H
• Description: KRAS proteins aremembers of the superfamily of small GTP-binding proteins that function asmolecular switches controlling a variety of signaling and transport pathways.KRAS, one of three classic human Ras genes, is spliced to two differentisoforms, K-RAS4A and K-RAS4B. K-RAS4B is the predominant product of thealternative splicing pathway and the KRAS protein encoded by the commonlymutated Ras gene in human cancer. Protein preparation is 100% GDP-loaded,measured by HPLC.
• Source: E. coli
• Species: Human
• Form: Liquid in 64 mMTris-HCl, pH 7.2 + 10 mM MgCl2 + 5 mM DTE
• MolecularWeight: 21.4 kDa
• Purity: > 95% asdetermined by SDS-PAGE analysis
• Storage: Stable for 1 yearin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: KRAS

Gene Information

• Gene Name: KRAS v-Ki-ras2 Kirsten ratsarcoma viral oncogene homolog [ Homo sapiens ]
• Synonyms: KRAS; v-Ki-ras2Kirsten rat sarcoma viral oncogene homolog; NS; NS3; KRAS1; KRAS2; RASK2;KI-RAS; C-K-RAS; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; GTPase KRas; K-Ras 2;c-Ki-ras; oncogene KRAS2; K-ras p21 protein; OTTHUMP00000245391;OTTHUMP00000245393; c-Kirsten-ras protein; PR310 c-K-ras oncogene;transforming protein p21; cellular c-Ki-ras2 proto-oncogene; v-Ki-ras2Kirsten rat sarcoma 2 viral oncogene homolog; Kirsten rat sarcoma-2 viral(v-Ki-ras2) oncogene homolog
• Gene ID: 3845
• mRNA Refseq: NM_004985
• Protein Refseq: NP_004976
• MIM: 190070
• UniProt ID: P01116
• Chromosome Location: 12p12.1
• Pathway: ARMS-mediatedactivation; B cell receptor signaling pathway; Cell surface interactions atthe vascular wall; Developmental Biology; EGFR1 Signaling Pathway; Fc epsilonRI signaling pathway; G Protein Signaling Pathways; HTLV-I infection; IL-2Signaling Pathway;; MAPK signaling pathway; Natural killer cell mediatedcytotoxicity; Pancreatic cancer; RAF phosphorylates MEK; SOS-mediatedsignalling; T cell receptor signaling pathway
• Function: GDP binding; GMPbinding; GTP binding; GTPase activity; LRR domain binding; Ralguanyl-nucleotide exchange factor activity; nucleotide binding; proteinbinding