Description : |
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
109.6 kDa |
AA Sequence : |
MAARWSSENVVVEFRDSQATAMSVD CLGQHAVLSGRRFLYIVNLDAPFEG HRKISRQSKWDIGAVQWNPHDSFAH YFAASSNQRVDLYKWKDGSGEVGTT LQGHTRVISDLDWAVFEPDLLVTSS VDTYIYIWDIKDTRKPTVALSAVAG ASQVKWNKKNANCLATSHDGDVRIW DKRKPSTAVEYLAAHLSKIHGLDWH PDSEHILATSSQDNSVKFWDYRQPR KYLNILPCQVPVWKARYTPFSNGLV TVMVPQLRRENSLLLWNVFDLNTPV HTFVGHDDVVLEFQWRKQKEGSKDY QLVTWSRDQTLRMWRVDSQMQRLCA NDILDGVDEFIESISLLPEPEKTLH TEDTDHQHTASHGEEEALKEDPPRN LLEERKSDQLGLPQTLQQEFSLINV QIRNVNVEMDAADRSCTVSVHCSNH RVKMLVKFPAQYPNNAAPSFQFINP TTITSTMKAKLLKILKDTALQKVKR GQSCLEPCLRQLVSCLESFVNQEDS ASSNPFALPNSVTPPLPTFARVTTA YGSYQDANIPFPRTSGARFCGAGYL VYFTRPMTMHRAVSPTEPTPRSLSA LSAYHTGLIAPMKIRTEAPGNLRLY SGSPTRSEKEQVSISSFYYKERKSR RWKSKREGSDSGNRQIKAAGKVIIQ DIACLLPVHKSLGELYILNVNDIQE TCQKNAASALLVGRKDLVQVWSLAT VATDLCLGPKSDPDLETPWARHPFG RQLLESLLAHYCRLRDVQTLAMLCS VFEAQSRPQGLPNPFGPFPNRSSNL VVSHSRYPSFTSSGSCSSMSDPGLN TGGWNIAGREAEHLSSPWGESSPEE LRFGSLTYSDPRERERDQHDKNKRL LDPANTQQFDDFKKCYGEILYRWGL REKRAEVLKFVSCPPDPHKGIEFGV YCSHCRSEVRGTQCAICKGFTFQCA ICHVAVRGSSNFCLTCGHGGHTSHM MEWFRTQEVCPTGCGCHCLLESTFT RTRPLEQKLISEEDLAANDILDYKD DDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |