Recombinant Human WRN protein(Met1-Ile333), His-tagged

• Cat.No.: WRN-10H
• Product Overview: Recombinant Human WRN protein(Q14191) (Met1-Ile333) was expressed in E. coli, with a polyhistidine tag at the N-terminus.

Specification

• Source: E. coli
• Species: Human
• Tag: N-His
• Protein length: Met1-Ile333
• Form: Lyophilized from sterile 50mM PB, 500mM Nacl, pH 7.7.
• Molecular Mass: The recombinant Human WRN consists of 340 amino acids and predicts a molecular mass of 38.99 kDa.
• Endotoxin: < 1.0 EU per μg protein as determined by the LAL method.
• Purity: ≥ 90 % as determined by SDS-PAGE.
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: WRN Werner syndrome, RecQ helicase-like [ Homo sapiens ]
• Official Symbol: WRN
• Synonyms: WRN; Werner syndrome, RecQ helicase-like; Werner syndrome; Werner syndrome ATP-dependent helicase; RECQ3; RECQL2
• Gene ID: 7486
• mRNA Refseq: NM_000553
• Protein Refseq: NP_000544
• MIM: 604611
• UniProt ID: Q14191

Reviews

10/15/2022

Supports our research with high-quality data.

03/15/2021

Reliable partner for our protein experiments.

04/03/2017

Helps us achieve research milestones consistently.

Q&As

How do genetic mutations in the WRN gene affect its function?

Mutations in WRN can disrupt its enzymatic activities, leading to genomic instability and disease.

What are the implications of altered WRN activity in aging and age-related diseases?

Altered WRN activity is associated with accelerated aging and increased risk of age-related diseases.

What role does WRN play in DNA repair and replication?

WRN plays a crucial role in both DNA repair and replication processes.

How does WRN deficiency lead to Werner syndrome?

Deficiency in WRN leads to accelerated aging symptoms in Werner syndrome, due to impaired DNA repair.

What potential therapeutic approaches target WRN for treating Werner syndrome and other age-related conditions?

Therapies targeting WRN aim to enhance DNA repair mechanisms, potentially treating Werner syndrome and related conditions.

How does WRN interact with other proteins in the maintenance of genomic stability?

WRN cooperates with other proteins to ensure accurate DNA repair and replication.

What is the primary function of WRN in cellular processes?

WRN is involved in DNA repair and maintenance of genomic stability.