Recombinant Human WWTR1 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | WWTR1-2240H |
Product Overview : | WWTR1 MS Standard C13 and N15-labeled recombinant protein (NP_056287) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 44.1 kDa |
AA Sequence : | MNPASAPPPLPPPGQQVIHVTQDLD TDLEALFNSVMNPKPSSWRKKILPE SFFKEPDSGSHSRQSSTDSSGGHPG PRLAGGAQHVRSHSSPASLQLGTGA GAAGSPAQQHAHLRQQSYDVTDELP LPPGWEMTFTATGQRYFLNHIEKIT TWQDPRKAMNQPLNHMNLHPAVSST PVPQRSMAVSQPNLVMNHQHQQQMA PSTLSQQNHPTQNPPAGLMSMPNAL TTQQQQQQKLRLQRIQMERERIRMR QEELMRQEAALCRQLPMEAETLAPV QAAVNPPTMTPDMRSITNNSSDPFL NGGPYHSREQSTDSGLGLGCYSVPT TPEDFLSNVDEMDTGENAGQTPMNI NPQQTRFPDFLDCLPGTNVDLGTLE SEDLIPLFNDVESALNKSEPFLTWL TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | WWTR1 WW domain containing transcription regulator 1 [ Homo sapiens (human) ] |
Official Symbol : | WWTR1 |
Synonyms : | WWTR1; WW domain containing transcription regulator 1; WW domain-containing transcription regulator protein 1; DKFZp586I1419; TAZ; transcriptional coactivator with PDZ-binding motif; transcriptional co-activator with PDZ-binding motif; FLJ27004; FLJ45718; |
Gene ID : | 25937 |
mRNA Refseq : | NM_015472 |
Protein Refseq : | NP_056287 |
MIM : | 607392 |
UniProt ID : | Q9GZV5 |
Products Types
◆ Recombinant Protein | ||
WWTR1-10217M | Recombinant Mouse WWTR1 Protein, His (Fc)-Avi-tagged | +Inquiry |
WWTR1-2363H | Recombinant Human WWTR1 Protein, His (Fc)-Avi-tagged | +Inquiry |
WWTR1-5796H | Recombinant Human WWTR1 Protein (Met1-Leu400), N-His tagged | +Inquiry |
WWTR1-2480H | Recombinant human WWTR1, His-tagged | +Inquiry |
WWTR1-3589Z | Recombinant Zebrafish WWTR1 | +Inquiry |
◆ Lysates | ||
WWTR1-272HCL | Recombinant Human WWTR1 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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