| Description : |
Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
146.2 kDa |
| AA Sequence : |
MTADKLVFFVNGRKVVEKNADPETT LLAYLRRKLGLSGTKLGCGEGGCGA CTVMLSKYDRLQNKIVHFSANACLA PICSLHHVAVTTVEGIGSTKTRLHP VQERIAKSHGSQCGFCTPGIVMSMY TLLRNQPEPTMEEIENAFQGNLCRC TGYRPILQGFRTFARDGGCCGGDGN NPNCCMNQKKDHSVSLSPSLFKPEE FTPLDPTQEPIFPPELLRLKDTPRK QLRFEGERVTWIQASTLKELLDLKA QHPDAKLVVGNTEIGIEMKFKNMLF PMIVCPAWIPELNSVEHGPDGISFG AACPLSIVEKTLVDAVAKLPAQKTE VFRGVLEQLRWFAGKQVKSVASVGG NIITASPISDLNPVFMASGAKLTLV SRGTRRTVQMDHTFFPGYRKTLLSP EEILLSIEIPYSREGEYFSAFKQAS RREDDIAKVTSGMRVLFKPGTTEVQ ELALCYGGMANRTISALKTTQRQLS KLWKEELLQDVCAGLAEELHLPPDA PGGMVDFRCTLTLSFFFKFYLTVLQ KLGQENLEDKCGKLDPTFASATLLF QKDPPADVQLFQEVPKGQSEEDMVG RPLPHLAADMQASGEAVYCDDIPRY ENELSLRLVTSTRAHAKIKSIDTSE AKKVPGFVCFISADDVPGSNITGIC NDETVFAKDKVTCVGHIIGAVVADT PEHTQRAAQGVKITYEELPAIITIE DAIKNNSFYGPELKIEKGDLKKGFS EADNVVSGEIYIGGQEHFYLETHCT IAVPKGEAGEMELFVSTQNTMKTQS FVAKMLGVPANRIVVRVKRMGGGFG GKETRSTVVSTAVALAAYKTGRPVR CMLDRDEDMLITGGRHPFLARYKVG FMKTGTVVALEVDHFSNVGNTQDLS QSIMERALFHMDNCYKIPNIRGTGR LCKTNLPSNTAFRGFGGPQGMLIAE CWMSEVAVTCGMPAEEVRRKNLYKE GDLTHFNQKLEGFTLPRCWEECLAS SQYHARKSEVDKFNKENCWKKRGLC IIPTKFGISFTVPFLNQAGALLHVY TDGSVLLTHGGTEMGQGLHTKMVQV ASRALKIPTSKIYISETSTNTVPNT SPTAASVSADLNGQAVYAACQTILK RLEPYKKKNPSGSWEDWVTAAYMDT VSLSATGFYRTPNLGYSFETNSGNP FHYFSYGVACSEVEIDCLTGDHKNL RTDIVMDVGSSLNPAIDIGQVEGAF VQGLGLFTLEELHYSPEGSLHTRGP STYKIPAFGSIPIEFRVSLLRDCPN KKAIYASKAVGEPPLFLAASIFFAI KDAIRAARAQHTGNNVKELFRLDSP ATPEKIRNACVDKFTTLCVTGVPEN CKPWSVRVTRTRPLEQKLISEEDLA ANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
