Recombinant Monkey FGFR3 Protein, Fc-tagged, Alexa Fluor 555 conjugated

• Cat.No.: FGFR3-204CAF555
• Product Overview: A DNA sequence encoding the Monkey FGFR3 (XP_001101108.1) (Met1-Gly375) (Alexa Fluor 555 conjugated) was expressed with the Fc region of human IgG1 at the C-terminus.

Specification

• Source: HEK293
• Species: Monkey
• Tag: Fc
• Form: Lyophilized
• Molecular Mass: The recombinant cynomolgus FGFR3 is a disulfide-linked homodimer. The reduced monomer comprises 594 amino acids and has a calculated molecular mass of 65.1 kDa. The apparent molecular mass of the protein is approximately 99.9 kDa respectively in SDS-PAGE.
• Protein length: Met1-Gly375， 594
• Endotoxin: < 1.0 EU/ μg of the protein as determined by the LAL method.
• Purity: > 90 % as determined by SDS-PAGE
• Characteristic: Disulfide-linked homodimer
  Labeled with Alexa Fluor 555 via amines
  With an excitation and emission maximum of 555/565 nm, Alexa Fluor 555 can be efficiently excited using a 543 nm He-Ne laser line and detected under standard TRITC/Cy3 filters.
• Stability: Samples are stable for up to 12 months from date of receipt at -70 centigrade.
• Storage: Store it under sterile conditions at -70 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Lyophilized from sterile PBS, pH7.4.

Gene Information

• Gene Name: FGFR3fibroblast growth factor receptor 3 [Macaca fascicularis(crab-eating macaque) ]
• Official Symbol: FGFR3
• Synonyms: FGFR3; fibroblast growth factor receptor 3
• Gene ID: 102128947
• mRNA Refseq: XM_005554285
• Protein Refseq: XP_005554342

Reviews

01/13/2020

Researchers who have utilized FGFR3 protein praise its exceptional performance and reliability in their experiments.

03/26/2018

Its high sensitivity enables the identification of low abundance targets, making it highly valuable in immunological research.

08/29/2017

Its stability and compatibility with electron microscopy techniques make it an ideal candidate for studying protein structures at high resolution.

Q&As

How does FGFR3 testing assist in personalized medicine approaches?

FGFR3 testing helps identify specific genetic mutations, allowing for personalized treatment plans tailored to an individual's genetic profile.

Is FGFR3 testing routinely conducted in cancer diagnosis?

FGFR3 testing is becoming more common, especially in cases where specific cancers associated with FGFR3 mutations are suspected.

Can FGFR3 be a prognostic marker in cancer?

Yes, FGFR3 status can serve as a prognostic marker, influencing the prediction of disease progression and patient outcomes.

Are there targeted therapies based on FGFR3 in cancer treatment?

Yes, FGFR3-targeted therapies are being developed for cancer treatment, particularly for patients with FGFR3 mutations.

How is FGFR3 targeted in cancer therapy?

FGFR3-targeted therapies may involve small molecule inhibitors or monoclonal antibodies that specifically block the activity of mutated FGFR3.