Recombinant Mouse ABCC10 Protein Pre-coupled Magnetic Beads

• Cat.No.: ABCC10-195M-B
• Product Overview: The Recombnant protein was conjugated to magnetic beads. This ready-to-use, pre-coupled magnetic beads are in uniform particle size and narrow size distribution with large surface area, which is conducive to convenient and fast capture target molecules with high specificity and achieve magnetic separation. This product can be equipped with automation equipment for high-throughput operations.

Specification

• Source: HEK293
• Species: Mouse
• Form: Solution
• Particle size: ~2 μm
• Beads Surface: Hydrophilic
• Capacity: > 200 pmol rabbit IgG/ mg beads
• Applications: Immunoassay, In vitro diagnostics, cell sorting, Immunoprecipitation/Co-precipitation, Protein/antibody separation and purification.
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions.
• Storage: 2-8℃. Do not to freeze thaw the Beads
• Concentration: 10mg beads/mL
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Abcc10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 [ Mus musculus ]
• Official Symbol: ABCC10
• Gene ID: 224814
• mRNA Refseq: NM_145140.2
• Protein Refseq: NP_660122.1
• UniProt ID: Q8R4P9

Reviews

02/07/2022

Very good customer service

09/06/2021

Use well in WB

09/02/2020

High purity, good quality

Q&As

Dose ABCC10 related with gefitinib resistance in non-small cell lung cancer?

Yes. FTO/YTHDF2/ABCC10 axis played a role in intercellular transmission of GR cell-derived exosome-mediated gefitinib resistance both in vitro and in vivo.

Does the express of ABCC10 the same in different tumor cell?

No, the expression of ABCC10 are different in different tumor. The expression of ABCC10 in adenocarcinoma is higher than that in squamous cell carcinoma.

Where dose the ABCC10 most expressed?

The expression of ABCC10 was mainly located in cell membrane and cytoplasm.

Are genetic variants of ABCC10 associated with kidney tubular dysfunction?

Yes, ABCC10 single-nucleotide polymorphisms (SNPs) are associated with KTD.

Can CP55 inhibit the MDR of MRP7?

CP55 is not the inhibitor, but 5-cyano-6-phenylpyrimidin derivative CP55 was synthesized and found significantly reversal effect of multidrug resistance (MDR) mediated by ABCC10.

Can ABCC10 deletion prevent obesity?

ABCC10 Deficiency Prevents Diet-Induced Obesity. Studies have shown that the role of ATP-binding cassette transporter C10 (ABCC10) in regulating lipid metabolism. Furthermore, deletion of ABCC10 ameliorates diet-induced obesity in mice and leads to a better response during insulin and glucose tolerance tests.

Was ABCC10 expression correlated to human breast cancer?

Clinical sample analyses indicated that ABCC10 was more highly expressed in Her2+ and ER+ than in Her2-, ER-, and triple-negative breast cancer.

Do you know which cell line can be used to study MRP7/ABCC10 drug resistance?

You could construct the drug-resistant stable cell by yourself. We used the paclitaxel-resistant human small cell lung cancer subline to study the resistance to paclitaxe.

Could ABCC10 transports Tenofovir(TFV)?

Yes. A study concluded that TFV is a substrate for ABCC10, and genetic variability within the ABCC10 gene may influence TFV renal tubular transport and contribute to the development of KTD.

Do you know the structure of ABCC10?

ABCC10 is located on the basolateral cell membrane and consists of 3 membrane-spanning domains (MSDs) and 2 nucleotide-binding domains (NBDs).

What can ABCC10 transport as a transporter?

ABCC10 is a broad-specificity transporter of xenobiotics, including antitumor drugs, such as taxanes, epothilone B, vinca alkaloids, and cytarabine, as well as modulators of the estrogen pathway, such as tamoxifen.

Which inhibitors could inhibit the ABCC10 MDR function?

Cepharanthine, lapatinib, erlotinib, nilotinib, imatinib, sildenafil, and vardenafil, have been reported to overcome ABCC10-mediated MDR.

Do you have full length ABCC10?

Yes, you could find it on our subsite, please contact us for more information.

What's the relationship between multidrug resistance protein 7 (MRP7/ABCC10) structure and function?

You can find the result in "Insights on the structure–function relationship of humanmultidrug resistance protein 7 (MRP7/ABCC10) frommolecular dynamics simulations and docking studies".