Recombinant Mouse ABHD2 Protein Pre-coupled Magnetic Beads
Cat.No. : | ABHD2-215M-B |
Product Overview : | The Recombnant protein was conjugated to magnetic beads. This ready-to-use, pre-coupled magnetic beads are in uniform particle size and narrow size distribution with large surface area, which is conducive to convenient and fast capture target molecules with high specificity and achieve magnetic separation. This product can be equipped with automation equipment for high-throughput operations. |
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Source : | HEK293 |
Species : | Mouse |
Form : | Solution |
Particle size : | ~2 μm |
Beads Surface : | Hydrophilic |
Capacity : | > 200 pmol rabbit IgG/ mg beads |
Applications : | Immunoassay, In vitro diagnostics, cell sorting, Immunoprecipitation/Co-precipitation, Protein/antibody separation and purification. |
Stability : | Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. |
Storage : | 2-8℃. Do not to freeze thaw the Beads |
Concentration : | 10mg beads/mL |
Storage Buffer : | PBS buffer |
Gene Name : | Abhd2 abhydrolase domain containing 2 [ Mus musculus ] |
Official Symbol : | ABHD2 |
Gene ID : | 54608 |
mRNA Refseq : | NM_018811.6 |
Protein Refseq : | NP_061281.3 |
UniProt ID : | Q9QXM0 |
Products Types
◆ Recombinant Protein | ||
ABHD2-02H | Recombinant Human ABHD2 Protein, C-Myc/DDK-tagged | +Inquiry |
ABHD2-301H | Recombinant Human ABHD2 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
ABHD2-215M | Recombinant Mouse ABHD2 Protein, His (Fc)-Avi-tagged | +Inquiry |
ABHD2-248H | Recombinant Human ABHD2 Protein, His (Fc)-Avi-tagged | +Inquiry |
ABHD2-19R | Recombinant Rhesus Macaque ABHD2 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
ABHD2-9135HCL | Recombinant Human ABHD2 293 Cell Lysate | +Inquiry |
ABHD2-9134HCL | Recombinant Human ABHD2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionTthe mouse ABHD2 is expressed in vascular smooth muscle cells (SMCs) and that enhanced migration occurs with cultured vascular SMCs from Abhd2-deficient mice. Enhanced neointimal hyperplasia was observed in ABHD2-deficient mice.
This protein is strongly expressed in human spermatozoa. It is a key controller of sperm hyperactivation, which is a necessary step in allowing sperm to fertilize an egg.
Yes. Endogenous steroids and plant triterpenoids can influence CatSper activation via modulation of ABHD2.
A gel-based assay using MB064 was employed to identify novel inhibitors for ABHD2.
In the presence of Progesterone (or Pregnenolone Sulfate) it cleaves 2-arachidonoylglycerol (2AG) into glycerol and arachidonic acid (AA). 2AG inhibits sperm calcium channel CatSper, and so when ABHD2 removes 2AG calcium flows into the cell through the CatSper channel, leading to hyperactivation. ABHD2 is inhibited by testosterone, (as well as hydrocortisone, and the plant triterpenoids lupeol and pristimerin) which may prevent premature hyperactivation.
Suppression of ABHD2 may promote a malignant phenotype and poor prognosis for women with serous ovarian cancer.
The human ABHD2 protein sequence shows an α/β hydrolase domain with conserved GXSXG lipase motif. To study the role of this conserved GXSXG domain, ABHD2 was cloned, overexpressed and the recombinant protein was used for in vitro enzyme assays. The results obtained with His-tag purified recombinant ABHD2 protein clearly displayed both TAG lipase and ester hydrolase activities.
The ABHD2 gene is down regulated in the lungs of people with Emphysema. ABHD2 is important in maintaining the structural integrity of the lungs, and that disruption of phospholipid metabolism in the alveoli may lead to the development of emphysema. Increased expression has also been seen in the lungs of smokers.
The prognosis of the low-ABHD2 group patients was significantly worse as compared to that of the high group patients
By performing a functional genomics screen using an shRNA library to search for drivers of anoikis resistance in high-grade serous ovarian cancer, we can successfully identified three genes, ABHD2, ELAC2 and CYB5R3 whose downregulation increased resistance to anoikis.
Customer Reviews (5)
Write a reviewI have never in my life received products so quickly following my order!
Great performance in ELISA.
Good product.It is a first choice.
This antibody works very well for our samples.
This product provide detailed instructions, including application, storage condition, etc. Love it!
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