Recombinant Mouse Acsbg1 Protein, His-tagged

• Cat.No.: Acsbg1-1259M
• Product Overview: Recombinant Mouse Acsbg1 Protein (Met1-Asn271) with N-His tag was expressed in E. coli.

Specification

• Description: Predicted to enable long-chain fatty acid-CoA ligase activity and very long-chain fatty acid-CoA ligase activity. Acts upstream of or within response to glucocorticoid. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; face; genitourinary system; integumental system; and skeleton. Human ortholog(s) of this gene implicated in adrenoleukodystrophy. Orthologous to human ACSBG1 (acyl-CoA synthetase bubblegum family member 1).
• Source: E. coli
• Species: Mouse
• Tag: N-His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 34 kDa
  Accurate Molecular Mass: 44 kDa
• Protein length: Met1-Asn271
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: Acsbg1 acyl-CoA synthetase bubblegum family member 1 [ Mus musculus (house mouse) ]
• Official Symbol: Acsbg1
• Synonyms: Acsbg1; acyl-CoA synthetase bubblegum family member 1; BG1; Bgm; Lpd; R75185; GR-LACS; E230019G03Rik; long-chain-fatty-acid--CoA ligase ACSBG1; bubblegum; gonadotropin-regulated long chain acyl CoA synthetase; lipidosin; lipidosis-related protein lipidosin; lipodisin; EC 6.2.1.3
• Gene ID: 94180
• mRNA Refseq: NM_053178
• Protein Refseq: NP_444408
• UniProt ID: Q99PU5

Reviews

07/19/2020

The samples provided by the manufacturer allowed me to test out different proteins before committing to a larger purchase, which was extremely helpful.

04/23/2020

The manufacturer's consistency in delivering high quality proteins has made them my go-to supplier.

08/16/2019

I was impressed by the follow-up from the manufacturer's after-sales team, who ensured that I was satisfied with my purchase.

07/09/2019

A satisfying purchase

07/13/2018

All good. Will recommand to my other colleague

Q&As

What is the relationship between ACSBG1 and insulin resistance?

ACSBG1 knockout in animal models leads to improved insulin sensitivity, and ACSBG1 expression is upregulated in insulin-resistant states.

What is the primary tissue distribution of ACSBG1 expression?

ACSBG1 is primarily expressed in the liver and adipose tissue, but is also found in other tissues such as the brain.

What is the role of ACSBG1 in insulin signaling?

ACSBG1 is involved in insulin signaling by regulating the levels of diacylglycerols, which can activate PKCε and inhibit insulin signaling.

What is the mechanism of ACSBG1 regulation by PGC-1α?

PGC-1α regulates ACSBG1 expression by interacting with PPARα to increase transcription, as well as by promoting the acetylation of histones in the ACSBG1 promoter region.

What is the role of ACSBG1 in cancer?

ACSBG1 has been found to be upregulated in several types of cancer, including breast, prostate, and liver cancer, and may play a role in tumor growth and progression.

What is the role of ACSBG1 in lipid droplet formation?

ACSBG1 is involved in the formation of lipid droplets by promoting the esterification of fatty acids into triacylglycerols.

How is the expression of ACSBG1 regulated?

ACSBG1 expression is regulated by a number of transcription factors, including SREBP1c, PPARα, and PGC-1α, which are all involved in regulating lipid metabolism.

What is the role of ACSBG1 in non-alcoholic fatty liver disease (NAFLD)?

ACSBG1 expression is upregulated in the liver of individuals with NAFLD, and ACSBG1 knockout in animal models leads to reduced hepatic steatosis.

What is the mechanism of ACSBG1 regulation by PPARα?

PPARα regulates ACSBG1 expression by binding to a specific site in the ACSBG1 promoter and increasing transcription.

What is the substrate specificity of ACSBG1?

ACSBG1 has a broad substrate specificity and can activate a variety of long-chain fatty acids.