Recombinant Mouse Adcy4 protein, His & T7-tagged

• Cat.No.: Adcy4-6926M
• Product Overview: Recombinant Mouse Adcy4 aa. (Ile352~Val541 (Accession # Q91WF3)) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Source: E. coli
• Species: Mouse
• Tag: His & T7
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 24.7kDa
• Protein length: Ile352~Val541 (Accession # Q91WF3)
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Characteristic: The isoelectric point is 6.3.
• Applications: SDS-PAGE; WB; ELISA; IP
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: Adcy4 adenylate cyclase 4 [ Mus musculus (house mouse) ]
• Official Symbol: Adcy4
• Synonyms: Adcy4; adenylate cyclase 4; mKIAA4004; adenylate cyclase type 4; ATP pyrophosphate-lyase 4; adenylate cyclase type IV; adenylyl cyclase 4
• Gene ID: 104110
• mRNA Refseq: NM_080435.1
• Protein Refseq: NP_536683.1
• UniProt ID: Q91WF3

Q&As

Can Adcy4 be used as a biomarker for cancer diagnosis?

Adcy4 has the potential to be used as a biomarker for some types of cancer. Its overexpression has been linked to several types of cancer, including breast, colorectal, and lung cancer. However, further research is needed to determine its exact role as a biomarker, and more studies are needed to validate its utility as a diagnostic tool.

Are there any potential side effects of targeting Adcy4 with drugs?

There is always the potential for side effects with any drug targeting Adcy4. However, since this protein is expressed in a variety of tissues and plays a role in many different biological processes, any drug targeting Adcy4 would need to be designed specifically to minimize off-target effects.

Can Adcy4 be used as a therapeutic target in hypertension?

Yes, Adcy4 is a promising therapeutic target in hypertension. Experimental studies have shown that inhibiting Adcy4 activity can reduce blood pressure in animal models. Developing drugs that specifically target Adcy4 could provide a new and effective treatment option for hypertension.

Is there any therapeutic potential for Adcy4 in neurological disorders?

Yes, Adcy4 has potential therapeutic targets in neurological disorders such as Alzheimer's and Parkinson's. Studies suggest that Adcy4 plays a role in modulating neuronal excitability and plasticity, and targeting Adcy4 could lead to the development of new drugs for these disorders.

What techniques are used to study Adcy4 protein?

Several techniques are used to study Adcy4 protein, including gene expression analysis, immunohistochemistry, Western blotting, and proteomic approaches such as mass spectrometry. In addition, animal models and cell culture systems are used to study the functional role of Adcy4 in various biological processes.

Could targeting Adcy4 with drugs have potential side effects?

Yes, targeting Adcy4 with drugs could potentially have side effects, especially if the target is not selective. Adcy4 has a role in multiple cellular processes, and therefore it is crucial to carefully evaluate the potential drugs and their effects on other cellular processes to lessen unwanted side effects.

How long do researchers expect it will take to develop a drug that targets Adcy4?

Drug development is a complex and time-consuming process that can take several years or even decades. It depends on many factors, including the availability of funding, the success of preclinical studies, and the safety and efficacy of the drug in clinical trials. However, because Adcy4 is a promising target for several different diseases, there is likely to be ongoing research in this area for years to come.

Can Adcy4 protein be used as a diagnostic marker for diseases?

Adcy4 protein expression levels could potentially be used as a diagnostic marker for some diseases. For example, increased levels of Adcy4 have been associated with heart failure, and measuring Adcy4 expression may help with early diagnosis and patient monitoring.

Could Adcy4 research lead to the development of new drugs?

Yes, Adcy4 research could lead to the development of new drugs that target cAMP signaling pathways in a more specific and effective way than currently available treatments. This could lead to improved outcomes for patients with diseases such as hypertension and heart failure.

Could personalized medicine approaches be developed based on Adcy4 expression?

Yes, personalized medicine approaches could potentially be developed based on Adcy4 expression levels. Measuring Adcy4 expression could help identify patients who are more likely to respond to certain treatments and stratify patients into specific subgroups for more targeted therapies.

Can Adcy4 be used to develop new treatments for heart disease?

Yes, Adcy4 is a promising target for developing new treatments for heart disease. The protein plays a role in regulating cardiac function and has been linked to heart failure and other cardiovascular diseases. Inhibiting Adcy4 activity could help to improve cardiac function and reduce the risk of heart failure.

What are some potential applications of Adcy4 protein in medicine?

Adcy4 protein has potential applications in medicine for the treatment of several diseases, such as hypertension, heart failure, and certain types of cancer. Understanding the role of Adcy4 in these diseases could lead to the development of new druggable targets and therapies.

How is Adcy4 protein regulated in the body?

Adcy4 protein is regulated by a variety of mechanisms in the body. Some regulators of Adcy4 expression include transcription factors, post-translational modifications such as phosphorylation, and various signaling pathways that can either activate or inhibit Adcy4 activity.