Recombinant Mouse Alkbh7 Protein, Myc/DDK-tagged
Cat.No. : | Alkbh7-1602M |
Product Overview : | Purified recombinant protein of mouse full-length alkB, alkylation repair homolog 7 (E. coli) (cDNA clone MGC:39017 IMAGE:5364485), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
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Description : | May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 24.1 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Alkbh7 alkB homolog 7 [ Mus musculus (house mouse) ] |
Official Symbol : | Alkbh7 |
Synonyms : | Alkbh7; alkB homolog 7; Abh; Spa; Abh7; Spata11; 2310045B01Rik; 2510008E23Rik; alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial; alkB, alkylation repair homolog 7; alkylated DNA repair protein alkB homolog 7; probable alpha-ketoglutarate-dependent dioxygenase ABH7; spermatogenesis associated 11 |
Gene ID : | 66400 |
mRNA Refseq : | NM_025538 |
Protein Refseq : | NP_079814 |
UniProt ID : | Q9D6Z0 |
Products Types
◆ Recombinant Protein | ||
ALKBH7-478M | Recombinant Mouse ALKBH7 Protein, His (Fc)-Avi-tagged | +Inquiry |
ALKBH7-321H | Recombinant Human ALKBH7 Protein, His (Fc)-Avi-tagged | +Inquiry |
ALKBH7-2381Z | Recombinant Zebrafish ALKBH7 | +Inquiry |
ALKBH7-9588H | Recombinant Human ALKBH7, GST-tagged | +Inquiry |
ALKBH7-1559M | Recombinant Mouse ALKBH7 Protein | +Inquiry |
◆ Lysates | ||
ALKBH7-8899HCL | Recombinant Human ALKBH7 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (13)
Ask a questionYes, the ALKBH7 gene has been shown to be important for the proper maintenance of nervous system development and function.
The expression pattern of ALKBH7 gene showed broad, tissue specific and period specific.
Some studies have found that ALKBH7 gene is highly expressed in liver cancer cells and is closely related to the progression and prognosis of liver cancer.
Yes, some studies suggest that mutations in the ALKBH7 gene may promote the development and spread of tumors and may contribute to the development of related diseases such as neurological disorders.
The mRNA cap reader protein recognizes and binds to the 3' end of a methylated RNA molecule. Its function is to help transcription factors effectively bind to mRNA, thus promoting the normal process of protein production.
Some diseases that are known to be related to the ALKBH7 gene include liver cancer, pancreatic cancer, lung cancer, schizophrenia, and Alzheimer's disease.
At present, some inhibitors targeting ALKBH7 gene have been developed, such as plant silicates and so on.
ALKBH7 regulates RNA methylation and demethylation, and is involved in cellular processes such as RNA stability, transcription and translation.
ALKBH7 gene is highly expressed in sperm, but the expression rate of ALKBH7 gene in other tissues and cell types varies with physiological activity and different developmental stages.
ALKBH7 gene has been shown to participate in ATM/ATR signaling pathway, Wnt signaling pathway, NF-κB signaling pathway, etc.
Yes, mutations in the ALKBH7 gene are heritable.
Although the ALKBH7 gene is widely expressed in multiple tissues, it has not been found to be involved in DNA repair processes, focusing on its role in RNA stability and transcription.
Studies of the ALKBH7 gene suggest that it may be involved in some cancers and tumours, but more extensive research is needed.
Customer Reviews (4)
Write a reviewGrowth factor activity that promotes cell growth and proliferation.
Easy to use, high stability, significant effect.
It has good application performance in immunodetection, such as ELISA, Western blot, etc.
Synthesized with high efficiency and yield.
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