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Recombinant Mouse Alkbh8 Protein, Myc/DDK-tagged

Cat.No. : Alkbh8-1603M
Product Overview : Purified recombinant protein of mouse full-length alkB homolog 8, tRNA methyltransferase (Alkbh8), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 74.8 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Alkbh8 alkB homolog 8, tRNA methyltransferase [ Mus musculus (house mouse) ]
Official Symbol : Alkbh8
Synonyms : ALKBH8; alkB, alkylation repair homolog 8 (E. coli); alkylated DNA repair protein alkB homolog 8; probable alpha-ketoglutarate-dependent dioxygenase ABH8; tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8; S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8; Abh8; 4930562C03Rik; 8030431D03Rik; 9430088N01Rik; MGC10235
Gene ID : 67667
mRNA Refseq : NM_026303
Protein Refseq : NP_080579
UniProt ID : Q80Y20

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (16)

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In which populations are mutations in the ALKBH8 gene associated? 04/23/2023

The mutation of ALKBH8 gene is related to individual heredity, age, gender and so on.

Can ALKBH8 gene mutation be modulated by lifestyle? 03/22/2023

Mutations in the ALKBH8 gene can be regulated and influenced by a healthy lifestyle.

What treatments can ALKBH8 gene mutations be treated by? 02/10/2023

There is currently no specific treatment for the ALKBH8 gene mutation, but treatments can be tailored to the symptoms that occur.

What diseases is the ALKBH8 gene associated with? 03/02/2022

The ALKBH8 gene has been linked to breast cancer, neurological diseases and more.

Does ALKBH8 gene mutation affect body immunity? 12/29/2021

Mutations in the ALKBH8 gene may affect the body's immunity, but the exact extent of the impact needs to be further studied.

Is ALKBH8 involved in the immune system? 08/22/2021

The ALKBH8 gene may affect the immune system, but the specific mechanism needs to be further studied.

In which tissues is ALKBH8 gene expressed? 07/30/2021

ALKBH8 gene is expressed in various tissues, including breast, ovary, kidney, brain and so on.

What is the relationship between ALKBH8 gene and hereditary diseases? 06/10/2021

Mutations in the ALKBH8 gene may cause some genetic diseases.

Are mutations in the ALKBH8 gene likely to have long-term consequences? 06/07/2021

Mutations in the ALKBH8 gene may lead to long-term health consequences that need to be studied further.

What physiological processes are related to the expression of ALKBH8 gene? 05/21/2021

The expression of ALKBH8 gene may be related to cell apoptosis, DNA repair and other physiological processes.

What is the inheritance mode of ALKBH8 gene mutation? 11/19/2020

The mutation of ALKBH8 gene may be inherited, and the specific inheritance mode needs to be further studied.

How is the mutation of ALKBH8 gene diagnosed? 04/13/2020

Mutations in the ALKBH8 gene can be diagnosed by methods such as gene sequencing.

What environmental factors are associated with ALKBH8 gene mutation? 04/06/2020

The mutation of ALKBH8 gene may be related to environmental factors such as chemicals and radiation.

What are the symptoms caused by mutation of ALKBH8 gene? 10/18/2019

Mutation of ALKBH8 gene may cause damage to DNA repair, resulting in cell apoptosis obstruction, cell mutation and other problems.

Does mutation of ALKBH8 gene affect fertility? 07/16/2019

Mutations in the ALKBH8 gene may affect fertility, but the exact extent needs to be further studied.

Is the mutation of ALKBH8 gene a cure? 06/01/2019

There is currently no specific cure for mutations in the ALKBH8 gene.

Customer Reviews (3)

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Reviews
10/31/2022

    Good stability and activity during long-term storage.

    03/03/2019

      It is effective and safe in clinical treatment.

      02/08/2019

        ALKBH8 is not structurally or functionally defective.

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