Recombinant Mouse Ambp Protein, His/GST-tagged
Cat.No. : | Ambp-224M |
Product Overview : | Recombinant Mouse Ambp(Arg18~Ala202) fused with His/GST tag at N-terminal was expressed in E. coli. |
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Description : | This gene encodes a fusion protein that undergoes proteolytic processing to generate two mature proteins: alpha-1-microglobulin (A1m) is a heme-binding plasma glycoprotein of the lipocalin superfamily of proteins that bind to hydrophobic molecules, whereas bikunin belongs to the superfamily of Kunitz-type protease inhibitors. The transgenic mice specifically lacking bikunin, but not A1m, exhibit female infertility and an increased sensitivity to lung metastasis. |
Source : | E. coli |
Species : | Mouse |
Tag : | His/GST |
Form : | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
Molecular Mass : | 53.0kDa |
Identity : | Reconstitute in PBS or others |
Protein length : | Arg18~Ala202 |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
Purity : | > 95% |
Applications : | Positive Control; Immunogen; SDS-PAGE; WB. If bio-activity of the protein is needed, please check active protein |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
Reconstitution : | Reconstitute in PBS or others |
Gene Name : | Ambp alpha 1 microglobulin/bikunin [ Mus musculus ] |
Official Symbol : | Ambp |
Synonyms : | AMBP; alpha 1 microglobulin/bikunin; protein AMBP; polyprotein; ulinastatin; Urinary Trypsin Inhibitor; UTI; ASPI; Itil; HI-30; Intin4; AI194774; |
Gene ID : | 11699 |
mRNA Refseq : | NM_007443 |
Protein Refseq : | NP_031469 |
Products Types
◆ Recombinant Protein | ||
Ambp-590M | Recombinant Mouse Ambp Protein, MYC/DDK-tagged | +Inquiry |
AMBP-500M | Recombinant Mouse AMBP Protein, His (Fc)-Avi-tagged | +Inquiry |
AMBP-128H | Recombinant Human AMBP Protein, His-tagged | +Inquiry |
AMBP-331H | Recombinant Human AMBP Protein, His (Fc)-Avi-tagged | +Inquiry |
AMBP-127H | Recombinant Human AMBP Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
AMBP-27H | Native Human AMBP | +Inquiry |
AMBP-5312H | Native Human Alpha-1-Microglobulin/Bikunin Precursor | +Inquiry |
◆ Lysates | ||
AMBP-001HCL | Recombinant Human AMBP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAMBP expression levels and isoform variations can serve as diagnostic biomarkers for inflammatory diseases, immune dysregulation, or infection, aiding in disease diagnosis, monitoring, and prognostication.
AMBP expression is regulated by genetic and epigenetic factors, including transcription factors, DNA methylation, and histone modifications, which influence its expression patterns in different cell types and disease contexts.
AMBP modulates immune cell activities by regulating cellular adhesion, migration, phagocytosis, cytokine production, and immune cell differentiation through intracellular signaling pathways, such as MAPK and NF-魏B pathways.
AMBP participates in the regulation of complement activation by interacting with complement components, controlling the formation of membrane attack complexes and modulating the inflammatory response.
Targeting AMBP for therapeutic interventions in immune-mediated disorders or inflammatory conditions can be achieved through approaches such as small molecule inhibitors, antibody-based therapies, or gene editing techniques.
AMBP plays important roles in the immune system, including regulating inflammatory responses, modulating complement activation, and contributing to host defense mechanisms.
AMBP is released or secreted by immune cells through various mechanisms, including vesicular trafficking, exosomes, or proteolytic cleavage, which can be exploited for therapeutic purposes or biomarker discovery.
AMBP contributes to tissue homeostasis and immune surveillance in different organs, such as the kidney, lung, or reproductive system, and its dysregulation can have implications in tissue damage, autoimmune diseases, or infections in specific organ systems.
AMBP interacts with various immune-related proteins, such as complement components C3 and C5, cytokines, and cell surface receptors, influencing immune cell functions, immune signaling, and inflammation processes.
The structural features of AMBP, including its two domains (伪1-microglobulin and bikunin), are crucial for its immune-related functions, protein-protein interactions, and stability.
Customer Reviews (3)
Write a reviewCompatibility with various protein modification detection methods.
Enhanced data reproducibility in protein quantification.
Comprehensive profiling of protein expression patterns.
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