Recombinant Mouse Arhgap17 Protein, Myc/DDK-tagged
Cat.No. : | Arhgap17-1680M |
Product Overview : | Purified recombinant protein of mouse full-length Rho GTPase activating protein 17 (Arhgap17), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
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Description : | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca2+-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 79.4 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Arhgap17 Rho GTPase activating protein 17 [ Mus musculus (house mouse) ] |
Official Symbol : | Arhgap17 |
Synonyms : | Arhgap17; Rho GTPase activating protein 17; N; Na; Ric; WBP1; Rich1; Wbp15; Nadrin; Nadrin2; 5730403H17Rik; rho GTPase-activating protein 17; WW domain-binding protein 15; neuron-associated developmentally regulated protein; rho-type GTPase-activating protein 17 |
Gene ID : | 70497 |
mRNA Refseq : | NM_001122643 |
Protein Refseq : | NP_001116115 |
UniProt ID : | Q3UIA2 |
Products Types
◆ Recombinant Protein | ||
Arhgap17-245M | Recombinant Mouse Arhgap17 Protein, His-tagged | +Inquiry |
ARHGAP17-419R | Recombinant Rat ARHGAP17 Protein, His (Fc)-Avi-tagged | +Inquiry |
ARHGAP17-763H | Recombinant Human ARHGAP17 protein, GST-tagged | +Inquiry |
ARHGAP17-763R | Recombinant Rat ARHGAP17 Protein | +Inquiry |
◆ Lysates | ||
ARHGAP17-8743HCL | Recombinant Human ARHGAP17 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThere is limited information on ARHGAP17 polymorphisms associated with phenotypic variations in humans. The genetic variations or single nucleotide polymorphisms (SNPs) within ARHGAP17 and their association with specific traits, diseases, or phenotypic variations have not been well-investigated. Further studies are necessary to understand the impact of ARHGAP17 polymorphisms on human phenotypes.
While there is limited research on the specific role of ARHGAP17 in cancer, dysregulation of Rho GTPases and other GAP proteins has been implicated in cancer progression. Since ARHGAP17 negatively regulates RhoA, alterations in its expression or function may impact tumor cell behavior, invasion, and metastasis. Further studies are needed to explore the potential involvement of ARHGAP17 in cancer.
The specific functional or regulatory interactions between ARHGAP17 and other GAP proteins have not been extensively studied. However, as ARHGAP17 belongs to the GAP family, there could be potential interactions with other GAP proteins that regulate Rho GTPases. Further research is needed to explore these possible interactions.
Currently, there are no known drugs or compounds specifically targeted towards ARHGAP17. However, since ARHGAP17 regulates RhoA signaling, drugs targeted at RhoA or other downstream effectors may indirectly affect ARHGAP17 function. Therapeutic strategies that modulate RhoA activity could potentially impact ARHGAP17-mediated processes.
Due to the limited understanding of ARHGAP17's function and its direct involvement in specific diseases, it is not currently considered a well-established therapeutic target. However, further research may uncover specific contexts where modulating ARHGAP17 activity could be beneficial, particularly in diseases related to abnormal Rho GTPase signaling.
Limited research has been conducted on the association of ARHGAP17 with human diseases. However, altered expression or mutations in Rho GTPases or other GAP proteins have been implicated in several diseases, including cancer, neurological disorders, and cardiovascular diseases. More studies are needed to determine if ARHGAP17 alterations contribute to disease development.
Customer Reviews (8)
Write a reviewThey may offer educational resources such as technical guides, protocols, and application notes, which can aid researchers in understanding the principles, techniques, and potential applications of ARHGAP17 protein in their studies.
These resources can enhance the efficiency and accuracy of experimental workflows and contribute to successful outcomes.
Their collaboration, expertise, and customized solutions contribute to the successful execution of experiments, reliable data generation, and the advancement of scientific knowledge in the field.
the manufacturer's support is crucial for researchers using ARHGAP17 protein in trials.
Its unwavering stability and functionality have significantly contributed to the success and validity of my experimental outcomes.
Trusting in its consistent results, I am able to embark on my research with assurance and optimism.
the ARHGAP17 protein stands out for its exceptional quality, coupled with the outstanding technical support delivered by the manufacturer.
I enthusiastically recommend the ARHGAP17 protein to fellow researchers who seek an unparalleled product accompanied by dedicated customer assistance.
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