Recombinant Mouse ARHGAP18 Protein Pre-coupled Magnetic Beads

• Cat.No.: ARHGAP18-672M-B
• Product Overview: The Recombnant protein was conjugated to magnetic beads. This ready-to-use, pre-coupled magnetic beads are in uniform particle size and narrow size distribution with large surface area, which is conducive to convenient and fast capture target molecules with high specificity and achieve magnetic separation. This product can be equipped with automation equipment for high-throughput operations.

Specification

• Source: HEK293
• Species: Mouse
• Form: Solution
• Particle size: ~2 μm
• Beads Surface: Hydrophilic
• Capacity: > 200 pmol rabbit IgG/ mg beads
• Applications: Immunoassay, In vitro diagnostics, cell sorting, Immunoprecipitation/Co-precipitation, Protein/antibody separation and purification.
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions.
• Storage: 2-8℃. Do not to freeze thaw the Beads
• Concentration: 10mg beads/mL
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Arhgap18 Rho GTPase activating protein 18 [ Mus musculus ]
• Official Symbol: ARHGAP18
• Gene ID: 73910
• mRNA Refseq: NM_176837.2
• Protein Refseq: NP_789807.1
• UniProt ID: Q8K0Q5

Reviews

06/16/2021

To summarize, the ARHGAP18 protein is a highly recommended asset for various research endeavors, including ELISA, protein electron microscopy structure analysis, and Western blotting.

05/20/2019

The manufacturer's commitment to customer satisfaction and their willingness to customize solutions based on specific experimental requirements is commendable.

01/06/2019

This level of sensitivity and specificity has streamlined my research and allowed for precise protein characterization.

08/08/2017

Choosing the ARHGAP18 protein from this manufacturer not only provides me with a superior product but also grants me access to unparalleled technical support.

05/20/2017

The manufacturer's extensive experience and expertise in the field of ARHGAP18 protein research make them a trusted partner.

12/23/2016

The manufacturer's commitment to customer satisfaction is unmatched.

05/08/2016

Its exceptional performance, coupled with its ability to generate clear and precise protein bands, make it an indispensable tool in achieving accurate and reliable results.

04/05/2016

The ARHGAP18 protein exhibits a high degree of specificity in various assays, ensuring accurate and reliable results.

Q&As

Is ARHGAP18 involved in any cellular processes related to cytoskeletal dynamics?

Yes, ARHGAP18 is involved in cellular processes related to cytoskeletal dynamics. It functions as a Rho GTPase activating protein (GAP), specifically targeting RhoA. By regulating the activity of RhoA, ARHGAP18 can affect actin cytoskeleton organization, cell adhesion, and cell migration. ARHGAP18's interaction with actin stress fibers and focal adhesions further supports its role in cytoskeletal dynamics.

Are there any known post-translational modifications of ARHGAP18?

Currently, there is limited information about post-translational modifications of ARHGAP18. However, it is known that some Rho GAP proteins can undergo phosphorylation, ubiquitination, or sumoylation, which can potentially regulate their activity or stability. Further research is necessary to determine if ARHGAP18 undergoes any specific post-translational modifications and their functional implications.

Are there any known tissue-specific expression patterns for ARHGAP18?

ARHGAP18 is found to be expressed in various tissues, but its expression levels can vary. Studies have shown higher expression levels in the brain, liver, and kidney, while lower expression is observed in other tissues such as the heart, muscle, and lung. However, tissue-specific expression patterns may also vary depending on developmental stages and physiological conditions.

Has ARHGAP18 been implicated in any other physiological or pathological processes?

ARHGAP18 has been implicated in various physiological and pathological processes. Apart from its potential involvement in cancer, neuronal development, and cytoskeletal dynamics, ARHGAP18 has been associated with liver function. Studies have shown that ARHGAP18 expression is regulated by liver-enriched transcription factors and its dysregulation may contribute to liver diseases such as fibrosis. Additionally, ARHGAP18 expression has been linked to adipogenesis and insulin signaling in white adipose tissue. Further research is needed to fully understand the extent of ARHGAP18's involvement in other physiological and pathological processes.

Is there any evidence suggesting a role for ARHGAP18 in neuronal development or synaptic function?

There is emerging evidence suggesting a role for ARHGAP18 in neuronal development and synaptic function. Studies have reported the expression of ARHGAP18 in the developing brain and its involvement in neurite outgrowth and axon guidance. Moreover, interactions between ARHGAP18 and other components of the synaptic machinery have been observed, suggesting a potential role in synaptic function. However, more research is needed to fully understand the specific mechanisms and implications of ARHGAP18 in neuronal development and synaptic activity.

Are there any known genetic variants or mutations in ARHGAP18 associated with diseases?

Currently, there is limited information on genetic variants or mutations specifically associated with ARHGAP18 and diseases. However, alterations in Rho GTPase signaling pathways, which include interaction partners of ARHGAP18, have been implicated in various diseases such as cancer, cardiovascular disorders, and neurological conditions. Further research is needed to explore if specific genetic variants or mutations in ARHGAP18 are linked to disease susceptibility or progression.

Can ARHGAP18 interact with other proteins or molecules?

ARHGAP18 can potentially interact with several proteins and molecules involved in RhoA signaling. It may interact with RhoA itself and other regulatory proteins, such as Rho guanine nucleotide exchange factors (GEFs) and Rho guanine nucleotide dissociation inhibitors (GDIs). These interactions contribute to the modulation of RhoA activity and downstream signaling.

What cellular processes or pathways are influenced by ARHGAP18?

ARHGAP18 mainly influences cellular processes involving RhoA signaling. It regulates actin cytoskeletal dynamics, cell migration, cell adhesion, and cell morphology. By inhibiting RhoA activity, ARHGAP18 promotes the formation of stress fibers and focal adhesions, thereby affecting various cellular processes.

Is there any evidence suggesting a link between ARHGAP18 and neurological disorders?

Currently, there is no direct evidence linking ARHGAP18 to neurological disorders. However, given its involvement in cytoskeletal dynamics and cellular processes relevant to neuronal function, it is possible that ARHGAP18 may play a role in neurodevelopmental or neurodegenerative disorders. Additional studies are required to explore any potential associations between ARHGAP18 and neurological conditions.

Is there any evidence suggesting a role for ARHGAP18 in cell proliferation or cell cycle regulation?

Currently, there is limited evidence linking ARHGAP18 to cell proliferation or cell cycle regulation. However, RhoA signaling has been implicated in these processes, and ARHGAP18's ability to negatively regulate RhoA activity suggests its potential involvement. Further investigation is required to elucidate the specific role of ARHGAP18 in cell proliferation and cell cycle control.

Does ARHGAP18 play a role in cancer progression or development?

The involvement of ARHGAP18 in cancer progression or development is not extensively studied. However, dysregulation of RhoA and its signaling pathway is implicated in various aspects of cancer, including cell migration, invasion, and metastasis. Thus, ARHGAP18 could potentially have a role in cancer by modulating RhoA activity, but further research is needed to determine its specific contributions.

Are there any known mutations or variants associated with ARHGAP18?

There are currently no reported genetic mutations or variants specifically associated with ARHGAP18. However, variations in other genes within the Rho GTPase signaling pathway or related genes could indirectly impact the function or regulation of ARHGAP18.

Does ARHGAP18 have any known interacting partners in signaling pathways?

ARHGAP18 can interact with various proteins involved in RhoA signaling pathways. For example, it may interact with Rho GEFs, such as ARHGEF11, which activates RhoA by promoting its GDP to GTP exchange. Additionally, ARHGAP18 may interact with Rho GDIs, such as ARHGDIA, which regulate the cycling of Rho GTPases between active and inactive states. These interactions allow ARHGAP18 to modulate RhoA signaling.

Are there any therapeutic implications related to ARHGAP18?

Due to its involvement in RhoA signaling and cellular processes such as cell migration, ARHGAP18 may have therapeutic implications for diseases characterized by dysregulated RhoA activity. Modulating ARHGAP18 or targeting its downstream pathways could potentially impact tumor metastasis, neurological disorders, or other conditions where RhoA signaling plays a significant role. However, more research is needed to establish the therapeutic potential of targeting ARHGAP18.