Recombinant Mouse ARHGAP33 Protein
Cat.No. : | ARHGAP33-1872M |
Product Overview : | Recombinant Mouse ARHGAP33 full length or partial length protein was expressed. |
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Source : | Mammalian Cells |
Species : | Mouse |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC. |
Storage Buffer : | PBS buffer |
Gene Name : | Arhgap33 Rho GTPase activating protein 33 [ Mus musculus ] |
Official Symbol : | ARHGAP33 |
Gene ID : | 233071 |
mRNA Refseq : | NM_178252.2 |
Protein Refseq : | NP_839983.1 |
MIM : | |
UniProt ID : | Q80YF9 |
Products Types
◆ Recombinant Protein | ||
ARHGAP33-681M | Recombinant Mouse ARHGAP33 Protein, His (Fc)-Avi-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (13)
Ask a questionThere is limited information on the specific interactors or binding partners of ARHGAP33. However, Rho GTPases, namely RhoA, Rac1, and Cdc42, are known to interact with various RhoGAP proteins, and it is likely that ARHGAP33 interacts with these Rho GTPases as well.
Beyond its potential roles in cancer progression and immune response regulation, there is currently limited information on the involvement of ARHGAP33 in other physiological processes or diseases. Further studies may uncover its potential associations with various cellular processes, physiological functions, or disease conditions.
While the exact role of ARHGAP33 in neurodevelopmental disorders is not well-established, dysregulation of Rho GTPases and their regulators has been implicated in various neurodevelopmental conditions. Therefore, it is conceivable that dysregulation of ARHGAP33 may contribute to neurodevelopmental disorders, but more research is needed to fully understand its potential involvement.
The involvement of ARHGAP33 in neuronal development or synaptic function has not been well-studied. However, Rho GTPase signaling and RhoGAP proteins have been implicated in these processes. They play roles in neuronal migration, axon guidance, dendritic spine formation, synaptic plasticity, and neurotransmitter release. Therefore, it is plausible that ARHGAP33 may have functions in neuronal development and synaptic function, but more research is required to determine its specific roles in these processes.
Currently, there is no direct evidence linking ARHGAP33 to cancer. However, dysregulation of Rho GTPase signaling and RhoGAP proteins has been associated with cancer progression and metastasis in general. Since ARHGAP33 is a RhoGAP protein, it is possible that it may indirectly affect cancer related processes. Further studies are needed to investigate the potential involvement of ARHGAP33 in cancer development and progression.
As of now, there are no known specific drugs or compounds that target ARHGAP33. However, targeting the Rho GTPase signaling pathway, which is regulated by RhoGAP proteins, has been explored as a therapeutic approach in various diseases, including cancer, cardiovascular diseases, and neurological disorders. It is possible that future studies may identify potential candidates for targeting ARHGAP33 or its downstream signaling pathway.
ARHGAP33 is expressed in the brain, suggesting potential roles in neuronal function. While specific studies on ARHGAP33 in neurons are limited, it is known that Rho GTPases and their regulators, including RhoGAPs, are crucial for various neuronal processes such as neurite outgrowth, axon guidance, and synaptic plasticity. Further research may uncover specific roles of ARHGAP33 in neuronal function.
Currently, there is limited information on knockout or overexpression studies specifically focused on ARHGAP33. However, some studies have investigated the functional roles of RhoGAP proteins in general, which indirectly shed light on the potential functions of ARHGAP33. Future studies utilizing ARHGAP33-specific knockouts or overexpression models may provide more insights into its biological functions.
Currently, there is limited information on genetic variants or mutations in ARHGAP33 associated with diseases. However, genetic variations in other RhoGAP genes have been implicated in several diseases, including cancer, developmental disorders, and neurological disorders. It is possible that genetic variants or mutations in ARHGAP33 may also contribute to certain diseases, but more research is needed to determine their specific associations.
ARHGAP33 acts as a RhoGAP protein by binding to the active, GTP-bound form of Rho GTPases and stimulating their intrinsic GTPase activity. This leads to the inactivation of Rho GTPases and downregulates their signaling pathways.
While the precise role of ARHGAP33 in cell migration or cytoskeletal dynamics is not well-established, it is known that RhoGAP proteins modulate the activity of Rho GTPases, which are key regulators of cell migration, cytoskeletal dynamics, and actin remodeling. As ARHGAP33 belongs to the RhoGAP family, it is plausible that ARHGAP33 may contribute to cell migration or cytoskeletal dynamics, but more research is needed to clarify its specific involvement.
The downstream effectors of Rho GTPases regulated by ARHGAP33 can vary depending on the specific Rho GTPase involved. They can include various pathways involved in actin cytoskeleton dynamics, cell migration, cell adhesion, and gene expression.
The specific signaling pathways or transcription factors that regulate ARHGAP33 expression have not been well-characterized. However, studies have shown that ARHGAP33 expression can be induced by various stimuli, such as growth factors, cytokines, and cellular stress. Further research is needed to identify the specific signaling pathways and transcription factors involved in the regulation of ARHGAP33 expression.
Customer Reviews (8)
Write a reviewThe protein's interaction with other APC/C subunits enables the study of its function and the investigation of its involvement in various cellular processes.
Their team of experts has been instrumental in resolving any queries or challenges I encountered regarding the application and utilization of the ARHGAP33 protein.
Its unwavering stability and functionality have significantly contributed to the success and validity of my experimental outcomes.
This guidance allows me to design and implement experiments effectively while adhering to best practices, enhancing the reliability and reproducibility of my results.
the manufacturer's commitment to quality control is essential in achieving reliable and consistent outcomes
Trusting in its consistent results, I am able to embark on my research with assurance and optimism.
I am profoundly impressed by the technical support rendered by the manufacturer.
The manufacturer of ARHGAP33 protein plays a crucial role in supporting my research efforts.
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