Recombinant Mouse ARHGAP36 Protein, His (Fc)-Avi-tagged

• Cat.No.: ARHGAP36-682M
• Product Overview: Recombinant Mouse ARHGAP36 with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Mouse
• Tag: His (Fc)-Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Arhgap36 Rho GTPase activating protein 36 [ Mus musculus ]
• Official Symbol: ARHGAP36
• Gene ID: 75404
• mRNA Refseq: NM_001081123.1
• Protein Refseq: NP_001074592.1
• UniProt ID: B1AUC7

Reviews

01/27/2023

The ARHGAP36 protein's robustness and stability have contributed significantly to the success of my experiments, enabling precise and reproducible measurements.

12/24/2022

The technical support provided by the manufacturer is invaluable in overcoming experimental hurdles and optimizing the utilization of ARHGAP36 protein.

11/09/2020

In addition to providing impeccable protein quality, the manufacturer offers excellent technical support that can effectively address any challenges I may encounter during my research.

09/10/2020

Another crucial aspect where the manufacturer excels is their efficient supply chain management.

03/01/2020

Its ability to preserve structural integrity and facilitate high-resolution imaging has greatly enhanced my understanding of protein complexes and their interactions.

04/23/2019

Their knowledgeable and responsive team of experts is readily available to provide guidance, troubleshooting assistance, and answer any inquiries or concerns I may have.

12/13/2018

The ARHGAP36 protein offered by the manufacturer is of exceptional quality, making it an ideal choice to fulfill my experimental needs.

10/03/2016

Furthermore, the ARHGAP36 protein has demonstrated great utility in protein electron microscopy structure analysis.

05/05/2016

The ARHGAP36 protein's reliability and ease of use have made it an essential component of my structural investigations.

01/25/2016

I highly recommend the ARHGAP36 protein for a wide range of research applications.

Q&As

Can ARHGAP36 be targeted for therapeutic purposes?

As ARHGAP36 is involved in various cellular processes, it holds therapeutic potential. By modulating its activity or targeting its interactions, it may be possible to design interventions for neurodevelopmental disorders, cancer, or other conditions influenced by ARHGAP36.

Are there any drugs or compounds that specifically target ARHGAP36?

At present, there are no known drugs or compounds that specifically target ARHGAP36. However, ongoing research may identify potential molecules that can modulate its activity in the future.

What tissues express ARHGAP36?

ARHGAP36 is expressed in various tissues, including the brain, heart, liver, and skeletal muscle. Its expression is developmentally regulated.

How does ARHGAP36 regulate actin dynamics?

ARHGAP36 acts as a Rho GTPase-activating protein (GAP), promoting the inactivation of Rho GTPases and influencing actin cytoskeleton rearrangements involved in cell migration, adhesion, and shape changes.

Does ARHGAP36 have any known post-translational modifications?

Post-translational modifications of ARHGAP36, such as phosphorylation or ubiquitination, have not been extensively studied. More research is needed to elucidate the potential impact of such modifications on ARHGAP36 function.

Are there any known genetic mutations or variants in ARHGAP36?

Yes, several genetic mutations and variants have been identified in ARHGAP36. Some studies have linked specific mutations to neurodevelopmental disorders, such as intellectual disability and autism spectrum disorders.

How is ARHGAP36 regulated at the transcriptional level?

The transcriptional regulation of ARHGAP36 is not well characterized. Further studies are required to understand the specific transcription factors and regulatory elements that control its expression.

What are the potential implications of ARHGAP36 dysfunction in neurodevelopmental disorders?

ARHGAP36's role in neuronal morphogenesis suggests that dysfunction or alteration of its activity may contribute to neurodevelopmental disorders by affecting neuronal connectivity and synaptic function.

Are there any animal models used to study ARHGAP36?

Yes, animal models like mice and zebrafish are used to study ARHGAP36. Knockout or mutant models can provide insights into the consequences of ARHGAP36 disruption in development and disease.

What are the interactions of ARHGAP36 with other proteins?

ARHGAP36 interacts with Rho GTPases (such as RhoA and Rac1), NMDA receptor subunits, and PSD-95, suggesting its involvement in complex signaling networks within cells.

How does ARHGAP36 contribute to synaptic plasticity?

ARHGAP36 interacts with NMDA receptor subunits and PSD-95, suggesting its involvement in synaptic signaling and plasticity. It likely influences the dynamics of dendritic spines, which play a role in synaptic remodeling and learning processes.

How does ARHGAP36 contribute to neuronal morphogenesis?

ARHGAP36 regulates dendritic arborization and spine development, which are important for proper neuronal connectivity and synaptic function.

What are the potential roles of ARHGAP36 in cancer?

While the exact role of ARHGAP36 in cancer is not fully understood, studies have suggested its involvement in tumor progression and metastasis. It may regulate cell migration and invasion, potentially contributing to cancer cell dissemination.

Is ARHGAP36 involved in any signaling pathways?

ARHGAP36 has been implicated in several signaling pathways, including the Rho GTPase signaling pathway and the NMDA receptor signaling pathway. It may act as a modulator or downstream effector of these pathways, contributing to their overall cellular effects.