Recombinant Mouse ARHGAP40 Protein, His (Fc)-Avi-tagged
Cat.No. : | ARHGAP40-683M |
Product Overview : | Recombinant Mouse ARHGAP40 with His (Fc)-Avi tag was expressed and purified |
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Source : | HEK293 |
Species : | Mouse |
Tag : | His (Fc)-Avi |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Purity : | ≥85% by SDS-PAGE |
Stability : | Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | PBS buffer |
Gene Name : | Arhgap40 Rho GTPase activating protein 40 [ Mus musculus ] |
Official Symbol : | ARHGAP40 |
Gene ID : | 545481 |
mRNA Refseq : | NM_001145015.1 |
Protein Refseq : | NP_001138487.1 |
UniProt ID : | E9Q6X9 |
Products Types
◆ Recombinant Protein | ||
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ARHGAP40-1876M | Recombinant Mouse ARHGAP40 Protein | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionARHGAP40 is mainly associated with the Rho GTPase signaling pathway. It acts as a negative regulator by inactivating Rho GTPases, which are involved in various cellular processes like cell migration, cytoskeletal dynamics, and cell adhesion.
The specific interacting partners of ARHGAP40 are not well characterized. However, as a Rho GTPase-activating protein (RhoGAP), ARHGAP40 may interact with various Rho GTPases, such as RhoA, Rac1, and Cdc42, to regulate their activity. Additionally, it is possible that ARHGAP40 interacts with other proteins or signaling molecules involved in cellular processes, but further research is needed to determine its exact interacting partners.
Currently, there are no reported diseases or disorders directly associated with ARHGAP40 mutations. However, it is possible that mutations in ARHGAP40 or dysregulation of its expression or activity could play a role in various diseases or conditions. Further research is needed to explore any potential links between ARHGAP40 mutations and specific pathology.
The transcriptional regulation of ARHGAP40 has not been extensively studied, and there are no well-established transcription factors known to directly regulate its expression. However, computational analysis of the ARHGAP40 gene promoter region suggests potential binding sites for various transcription factors, including SP1, AP1, and NF-κB. Experimental studies are needed to validate the actual transcription factors involved in regulating ARHGAP40 expression.
Yes, ARHGAP40 contains several functional domains. It possesses a Rho-GAP domain, which is responsible for the GTPase-activating activity towards Rho GTPases. Additionally, it contains a coiled-coil domain, which is involved in protein-protein interactions.
There is limited evidence suggesting a potential role for ARHGAP40 in cell proliferation or cell cycle regulation. In some studies, ARHGAP40 has been implicated in regulating cell division and proliferation in specific cell types. However, the exact mechanisms and extent of its involvement in these processes require further investigation.
While specific binding partners of ARHGAP40 have yet to be identified, it is likely to interact with Rho GTPases due to its role in regulating their activity. Additionally, it may interact with other proteins involved in cytoskeletal dynamics and cellular processes related to Rho GTPase signaling pathways.
Although the specific roles of ARHGAP40 in neuronal development and function are not well characterized, its involvement in the regulation of Rho GTPases suggests its potential importance in these processes. Rho GTPases play critical roles in neuronal morphology, axon guidance, and synapse formation. Further research is needed to elucidate the precise functions of ARHGAP40 in neuronal processes.
The potential role of ARHGAP40 in immune system function is not well understood. However, Rho GTPases, which can be regulated by ARHGAP40, have been implicated in various immune cell functions like migration, adhesion, phagocytosis, and cytokine production. It is possible that ARHGAP40 could indirectly influence immune system function through its regulation of Rho GTPases, but further research is required to determine its specific role in immune cell biology.
At present, there is limited information linking ARHGAP40 to human disorders or genetic conditions. Further research is necessary to investigate its potential involvement in diseases and identify any associated mutations or variations.
Although specific interacting proteins of ARHGAP40 in neuronal processes have not been extensively identified, it is likely to interact with other molecules involved in Rho GTPase signaling, such as Rho guanine nucleotide exchange factors (GEFs) and Rho GTPase effectors, to regulate neuronal functions such as axon outgrowth and synapse formation.
As of now, there is limited research exploring the potential involvement of ARHGAP40 in neurological disorders or cancer. However, since dysregulation of Rho GTPase signaling pathways has been implicated in these diseases, it is possible that alterations in ARHGAP40 expression or activity could contribute to their development. Further studies are needed to uncover its potential roles in disease contexts.
As of now, there are no established animal models specifically targeting ARHGAP40. However, general knockout or knockdown studies of Rho GTPase regulators or related molecules may indirectly provide insights into the function of ARHGAP40.
Currently, there are no specific animal models or knockout studies available for ARHGAP40. Creating animal models or conducting knockout studies could provide valuable insights into the physiological functions and consequences of ARHGAP40 deficiency in neuronal development and function.
Currently, there are no known small molecules or specific inhibitors targeting ARHGAP40. Developing specific inhibitors or modulators of ARHGAP40 activity could be a potential avenue for future therapeutic interventions or research.
Currently, there is limited information available regarding mutations or genetic variations in ARHGAP40 associated with human diseases. Further studies are needed to determine the specific impact of mutations in ARHGAP40 on disease development.
There is limited evidence suggesting a potential role for ARHGAP40 in cancer. In some studies, alterations in ARHGAP40 expression levels have been observed in certain types of cancer, including colorectal cancer and hepatocellular carcinoma. However, more research is required to establish a definitive role for ARHGAP40 in cancer development or progression.
Due to its involvement in the regulation of Rho GTPases, ARHGAP40 may have therapeutic implications in conditions where Rho GTPase dysregulation is implicated, such as cancer or neurological disorders. However, more research is required to fully understand its implications and identify potential therapeutic targets.
As a RhoGAP, ARHGAP40 is expected to play a role in cytoskeletal organization. Rho GTPases, such as RhoA, Rac1, and Cdc42, are known regulators of actin cytoskeleton dynamics. By catalyzing the hydrolysis of GTP to GDP on Rho GTPases, ARHGAP40 may modulate their activity and subsequently influence cytoskeletal organization and dynamics. However, further studies are necessary to elucidate the specific role of ARHGAP40 in cytoskeletal regulation.
Post-translational modifications of ARHGAP40 have not been extensively studied. It is unclear if ARHGAP40 can be phosphorylated or undergo other modifications like acetylation or ubiquitination.
Customer Reviews (8)
Write a reviewThis specificity enables precise quantification and characterization of ARHGAP40 and its interactions with other molecules or proteins of interest.
Its resistance to degradation and denaturation allows for longer storage times and repeated use without compromising its performance or functionality.
They actively engage with the scientific community, staying up-to-date with the latest advancements related to ARHGAP40 protein and sharing this valuable information.
When used in Western blotting experiments, the ARHGAP40 protein produces distinct protein bands, allowing for easy visualization and interpretation.
In addition to the impeccable protein quality, the manufacturer provides excellent technical support that can effectively address any challenges I may encounter during my experiments.
ARHGAP40 protein is known for its stability and robustness, making it suitable for a wide range of experimental conditions.
The technical support provided by the manufacturer is invaluable in resolving any potential roadblocks and optimizing the utilization of ARHGAP40 protein.
This reliable supply chain management guarantees uninterrupted access to the protein, allowing me to plan and conduct my experiments with confidence and without concern for availability issues.
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