Recombinant Mouse Arpc4 protein, His-tagged
Cat.No. : | Arpc4-1694M |
Product Overview : | Recombinant Mouse Arpc4 aa. (Ala79~Phe164 (Accession # P59999)) fused with N-terminal His tag was produced in E. coli cells. |
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Source : | E. coli |
Species : | Mouse |
Tag : | His |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 12.0kDa |
Protein length : | Ala79~Phe164 (Accession # P59999) |
Endotoxin : | <1.0EU per 1ug (determined by the LAL method) |
Purity : | >95% |
Applications : | SDS-PAGE; WB; ELISA; IP. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
Isoelectric Point : | 6.4 |
Gene Name : | Arpc4 actin related protein 2/3 complex, subunit 4 [ Mus musculus (house mouse) ] |
Official Symbol : | Arpc4 |
Synonyms : | Arpc4; actin related protein 2/3 complex, subunit 4; 20kDa; p20-Arc; AI327076; 5330419I20Rik; actin-related protein 2/3 complex subunit 4; arp2/3 complex 20 kDa subunit |
Gene ID : | 68089 |
mRNA Refseq : | NM_001170485.1 |
Protein Refseq : | NP_001163956.1 |
UniProt ID : | P59999 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionYes, ARPC4 expression can be influenced by extracellular signals. Various signaling pathways, such as the Rho GTPase pathway and growth factor signaling, can activate or inhibit the expression of genes encoding ARPC4 and other subunits of the ARP2/3 complex, thereby modulating actin cytoskeleton dynamics.
At present, there are no specific drugs or compounds known to directly modulate ARPC4 activity. However, targeting actin cytoskeleton dynamics and actin regulatory proteins that indirectly affect ARPC4 function has shown potential in preclinical studies as therapeutic approaches for various diseases.
Mutations in the ARPC4 gene have not been directly linked to any specific diseases. However, dysregulation of the ARP2/3 complex, including ARPC4, has been implicated in several pathological conditions such as cancer metastasis, neurological disorders, and immune system dysfunction.
ARPC4 is considered a ubiquitously expressed protein, meaning it is expressed in a wide range of tissues and cell types throughout the body. Its expression is necessary for essential cellular processes involving actin cytoskeleton dynamics.
Yes, ARPC4 interacts with other subunits of the ARP2/3 complex, including ARPC1, ARPC2, ARPC3, ARPC5, and ARPC6. Additionally, ARPC4 can interact with actin-binding proteins, such as cortactin and coronin, which regulate actin filament assembly and stability.
Yes, alterations in ARPC4 expression levels can impact cell migration. The ARP2/3 complex, including ARPC4, is essential for actin filament nucleation and branching, which are crucial for cell motility. Changes in ARPC4 expression can disrupt proper actin cytoskeletal dynamics, impairing cell migration.
Yes, changes in ARPC4 expression can impact cell division. The ARP2/3 complex, including ARPC4, is involved in actin-dependent processes during cell division, such as cytokinesis and chromosome segregation. Disruption of ARPC4 expression can lead to defects in these cellular processes.
Customer Reviews (3)
Write a reviewRenowned for its reliability and consistency, this protein offers researchers the confidence to achieve accurate and reproducible results in their studies.
One notable advantage of the ARPC4 protein is the excellent technical support provided by its manufacturer.
The ARPC4 protein is known for its exceptional quality, making it a highly suitable choice for meeting diverse experimental needs.
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