Recombinant Mouse Art2a Protein, His (Fc)-Avi-tagged

• Cat.No.: Art2a-762M
• Product Overview: Recombinant Mouse Art2a with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Mouse
• Tag: His (Fc)-Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Art2a-ps ADP-ribosyltransferase 2a, pseudogene [ Mus musculus ]
• Official Symbol: ART2A-PS
• Gene ID: 11871
• mRNA Refseq: NM_007490.1
• Protein Refseq: NP_031516.1
• UniProt ID: P17981

Reviews

07/21/2022

The Art2a protein boasts remarkable stability, allowing for extended storage without compromising its integrity or performance.

01/13/2020

This has greatly facilitated my experimental workflow, ensuring a readily available and dependable protein source whenever I need it.

03/26/2018

Its high quality, coupled with the manufacturer's exceptional technical support, make it a reliable and effective choice for addressing my scientific inquiries.

Q&As

Are there any therapeutic applications targeting Art2a?

Currently, there are no specific therapeutics targeting Art2a for direct modulation. However, research on ADP-ribosylation and its associated pathways may have therapeutic implications in the future.

Does Art2a activity change under pathological conditions?

The dysregulation of ADP-ribosylation, including Art2a activity, has been implicated in various diseases, such as cancer and inflammatory disorders. However, the specific role of Art2a in these conditions requires further investigation.

Are there any known diseases or disorders associated with mutations in the Art2a gene?

Mutations in the Art2a gene have not been directly linked to specific diseases or disorders in humans so far.

How does Art2a catalyze ADP-ribosylation?

Art2a transfers ADP-ribose from NAD+ to specific arginine residues on substrate proteins, modifying their structure and function.

Does Art2a have any non-enzymatic functions or interactions with other proteins?

Aside from its enzymatic role in ADP-ribosylation, Art2a does not have any known non-enzymatic functions or specific protein interactions.

What are some known substrates of Art2a?

Art2a primarily ADP-ribosylates arginine residues on various proteins including P2X purinergic receptors and certain immune cell markers such as CD4 and CD8.

Is the activity of Art2a influenced by any cofactors or regulators?

Art2a activity is dependent on the presence of NAD+ as a substrate, and it can also be influenced by extracellular ATP levels and extracellular calcium.