Recombinant Mouse As3mt Protein, Myc/DDK-tagged

• Cat.No.: As3mt-1732M
• Product Overview: Purified recombinant protein of mouse full-length arsenic (+3 oxidation state) methyltransferase (As3mt), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO3H2, which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me2As(O)-OH.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 41.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: As3mt arsenite methyltransferase [ Mus musculus (house mouse) ]
• Official Symbol: As3mt
• Synonyms: AS3MT; arsenic (+3 oxidation state) methyltransferase; arsenite methyltransferase; methyltransferase Cyt19; methylarsonite methyltransferase; S-adenosylmethionine:arsenic (III) methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase; Cyt19; 2310045H08Rik
• Gene ID: 57344
• mRNA Refseq: NM_020577
• Protein Refseq: NP_065602
• UniProt ID: Q91WU5

Reviews

09/13/2019

The AS3MT Protein has exceeded my expectations by consistently delivering outstanding results and providing exceptional technical support.

01/27/2019

In addition to its remarkable quality and exceptional technical support, the AS3MT Protein boasts an impressive range of applications.

06/05/2018

Their prompt assistance and willingness to go above and beyond to ensure my success have been immensely valuable.

Q&As

Why is the AS3MT protein important?

The AS3MT protein plays a crucial role in the detoxification and elimination of arsenic from the body, preventing its accumulation and potential toxicity.

How does the AS3MT protein interact with arsenic?

The AS3MT protein binds to and methylates inorganic arsenic, facilitating its conversion into organic arsenic metabolites that are easier to eliminate from the body.

Is the AS3MT protein involved in the metabolism of other substances?

The AS3MT protein is primarily associated with the metabolism of arsenic and has not been extensively linked to the metabolism of other substances.

What happens when the AS3MT protein is impaired or dysfunctional?

Impairment or dysfunction of the AS3MT protein can lead to reduced arsenic methylation ability, potentially increasing arsenic toxicity in the body.

Can alterations in AS3MT gene expression affect arsenic methylation?

Yes, alterations in AS3MT gene expression can influence the methylation capacity of arsenic, potentially leading to variations in arsenic toxicity levels.

Are there any genetic variations in the AS3MT gene?

Yes, genetic variations in the AS3MT gene have been identified and can influence the activity and expression of the AS3MT protein.

Is the AS3MT protein associated with any diseases or conditions?

The AS3MT protein is associated with arsenic-induced diseases and conditions, such as arsenic poisoning, arsenic-related cancers, and cardiovascular diseases.