Recombinant Mouse ASCL2 Protein (1-263 aa), His-Myc-tagged

• Cat.No.: ASCL2-2532M
• Product Overview: Recombinant Mouse ASCL2 Protein (1-263 aa) is produced by E. coli expression system. This protein is fused with a 10xHis tag at the N-terminal and a Myc tag at the C-terminal. Research Area: Developmental Biology. Protein Description: Full Length.

Specification

• Description: AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
• Source: E. coli
• Species: Mouse
• Tag: His-Myc
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 32.8 kDa
• Protein length: 1-263 aa
• AA Sequence: MEAHLDWYGVPGLQEASDACPRESC SSALPEAREGANVHFPPHPVPREHF SCAAPELVAGAQGLNASLMDGGALP RLMPTSSGVAGACAARRRQASPELL RCSRRRRSGATEASSSSAAVARRNE RERNRVKLVNLGFQALRQHVPHGGA NKKLSKVETLRSAVEYIRALQRLLA EHDAVRAALAGGLLTPATPPSDECA QPSASPASASLSCASTSPSPDRLGC SEPTSPRSAYSSEESSCEGELSPME QELLDFSSWLGGY
• Purity: > 85% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: Ascl2 achaete-scute complex homolog 2 (Drosophila) [ Mus musculus ]
• Official Symbol: ASCL2
• Synonyms: ASCL2; achaete-scute homolog 2; ASH-2; mASH-2; mammalian achaete scute homolog 2; Mash2; bHLHa45; 2410083I15Rik
• Gene ID: 17173
• mRNA Refseq: NM_008554
• Protein Refseq: NP_032580
• UniProt ID: O35885

Reviews

06/08/2022

The manufacturer's commitment to providing excellent technical support is highly valuable.

05/02/2018

The combination of high-quality ASCL2 protein and excellent technical support provided by the manufacturer makes them the ideal choice for my research.

07/15/2017

The ASCL2 protein offered by the manufacturer is of exceptional quality, and it meets the rigorous standards necessary for my experimental needs.

Q&As

Can ASCL2 induce pluripotency or cellular reprogramming?

ASCL2, along with other transcription factors and signaling molecules, has been used in combination to induce cellular reprogramming and pluripotency in certain contexts, demonstrating its ability to alter cell fate.

Does ASCL2 have any role in other tissues or organs?

ASCL2's primary role is in the gastrointestinal tract, but it may also have roles in other tissues and organs during development, including lung and pancreas.

Are there any known interacting partners of ASCL2?

ASCL2 interacts with various co-factors and proteins involved in stem cell regulation and development, including β-catenin, POU5F1 (Oct4), and SMAD proteins.

Is ASCL2 essential for the development of the gastrointestinal tract?

Yes, ASCL2 is crucial for the normal development of the gastrointestinal tract, particularly in regulating the differentiation and proliferation of intestinal stem cells.

Can ASCL2 be targeted for therapeutic interventions or drug discovery?

ASCL2 is being explored as a potential therapeutic target for colorectal cancer due to its involvement in promoting abnormal cell proliferation. Targeting ASCL2 may help inhibit tumor growth and progression.

How does ASCL2 regulate intestinal stem cells?

ASCL2 promotes the self-renewal of intestinal stem cells by activating specific gene expression programs involved in stem cell maintenance. It also regulates the balance between proliferation and differentiation of these cells.