Recombinant Mouse ATP2B1 Protein, His-tagged

• Cat.No.: ATP2B1-11M
• Product Overview: Recombinant Mouse ATP2B1 Protein, fused to His-tag, was expressed in E. coli.

Specification

• Description: Predicted to enable P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration and PDZ domain binding activity. Involved in several processes, including negative regulation of cytosolic calcium ion concentration; positive regulation of bone mineralization; and regulation of vascular associated smooth muscle contraction. Located in basolateral plasma membrane and immunological synapse. Is integral component of presynaptic membrane and integral component of synaptic vesicle membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human ATP2B1 (ATPase plasma membrane Ca2+ transporting 1).
• Source: E. coli
• Species: Mouse
• Tag: His
• Form: 50mM Tris, 0.3 M NaCl, 0.05% SKL, 1mM DTT, pH9.0.
• Molecular Mass: 13.8 kDa
• AA Sequence: MGSSHHHHHHSSGLVPRGSHMGDMA NNSVAYSGVKNSLKEANHDGDFGIT LTELRALMELRSTDALRKIQESYGD VYGICTKLKTSPNEGLSGNPADLER REAVFGKNFIPPKKPKTFLQLVWEA
• Purity: ＞90%
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 0.15 mg/ml

Gene Information

• Gene Name: Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 [ Mus musculus (house mouse) ]
• Official Symbol: ATP2B1
• Synonyms: Pmca1; 2810442I22Rik; E130111D10Rik
• Gene ID: 67972
• mRNA Refseq: NM_001359506
• Protein Refseq: NP_001346435
• MIM: 108731
• UniProt ID: G5E829

Reviews

03/14/2022

The bands of ATP2B1 in Western blot were regular in shape and showed good quality.

08/11/2021

ATP2B1 is really amazing. It maintains a very stable performance every time it is used. You can see that its production process is very careful.

10/06/2020

The high catalytic efficiency, safety, and expression level of this protein make it ideal for laboratory and practical applications.

Q&As

What are the pathways and forms of human ATP2Brecombinant proteins?

Human ATP2B1 recombinant protein can be administered by injection, intravenous drip, and other ways, which can be solution, powder or lyophilized powder.

What research has been carried out on human ATP2Brecombinant protein?

Previous studies have focused on the mechanism of ATP2B1 protein in hypertension and cardiovascular disease, the correlation of polymorphism, and the relationship between ATP2B1 variation and disease susceptibility.

What is the main mechanism of action of the human recombinant ATP2Bprotein?

ATP2B1 recombinant protein may affect physiological functions such as vasoconstriction and cardiac contraction by regulating calcium transport, thereby affecting hypertension and cardiovascular diseases.

What is the relationship between human ATP2Bgene expression and disease?

Some studies have found that the expression level of ATP2B1 gene is related to hypertension, heart disease and other diseases, but the detailed mechanism needs to be further explored and confirmed.

How is the therapeutic potential of the human recombinant ATP2Bprotein evaluated?

The evaluation of the therapeutic potential of human ATP2B1 recombinant protein mainly includes in vitro experiments, animal model studies and clinical trials.

Are there other related proteins that function similarly to ATP2B1?

Yes, in addition to ATP2B1, other calcium transporters (such as ATP2A1 and ATP2A2) have been found to be related to the regulation of intracellular and extracellular calcium balance.