Recombinant Mouse Atxn2, His-tagged

• Cat.No.: Atxn2-3688M
• Product Overview: Ataxin-2 (Atxn2), partial

Specification

• Source: E. Coli or Yeast
• Species: Mouse
• Tag: His
• Form: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Protein length: 1286
• Purity: >90%
• Notes: Small volumes of Atxn2 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
• Storage Buffer: PBS pH 7.4, 50% glycerol
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Information

• Gene Name: Atxn2 ataxin 2 [ Mus musculus ]
• Official Symbol: Atxn2
• Synonyms: ATXN2; ataxin 2; ataxin-2; spinocerebellar ataxia 2 homolog; spinocerebellar ataxia type 2 protein homolog; spinocerebellar ataxia 2 (olivopontocerebellar ataxia 2, autosomal dominant, ataxin 2); ATX2; Sca2; AW544490; 9630045M23Rik
• Gene ID: 20239
• mRNA Refseq: NM_009125
• Protein Refseq: NP_033151
• Chromosome Location: 5 F; 5
• Function: NOT DBD domain binding; protein C-terminus binding

Reviews

09/14/2021

The use of biodegradable materials by manufacturers in their packaging and shipping materials further reduces the carbon footprint and environmental impact.

03/20/2021

Because ATXN2 has a short half-life, it allows for a more flexible treatment regimen with dose adjustment based on patient response and tolerance.

11/06/2020

Meticulous attention to detail and quality control by the manufacturer ensured that the product did not contain any impurities or contaminants.

Q&As

Is there a drug therapy related to ATXN2 protein?

No specific drug therapy targeting ATXN2 protein has been identified. However, researchers are working hard to find ways to treat SCA2, including gene therapy and drug screening.

What is the regulatory mechanism of ATXN2 protein function?

The function of ATXN2 protein is regulated by a variety of regulatory mechanisms, including the binding of transcriptional regulators and post-translational modifications. These regulatory mechanisms ensure the adaptability and stability of ATXN2 protein.

Does ATXN2 protein interact with other proteins?

Yes, the ATXN2 protein interacts with multiple proteins to form complexes involved in the regulation of a variety of cellular functions. For example, ATXN2 interacts with PABPC1, RBFOX1 and other proteins and is involved in RNA stabilization and transcriptional regulation.

Which role of ATXN2 protein in humans?

ATXN2 protein is involved in the regulation of a variety of neural cell functions, including transcription regulation, RNA processing, cell transport, etc. It plays an important role in the development and functional maintenance of the nervous system.

Is ATXN2 protein associated with other neurological diseases?

In addition to SCA2, ATXN2 protein may be involved in the development and progression of other neurological diseases. For example, it may be associated with the pathogenesis of neurodegenerative diseases such as Parkinson's disease and muscular dystrophy. However, further studies are needed to confirm these associations.

What progress has been made in ATXN2 protein research?

The research of ATXN2 protein mainly focuses on understanding its functional regulation mechanism, its relationship with the pathogenesis of SCA2, and the search for therapeutic methods for SCA2. Currently, several important advances have been made regarding the function of ATXN2 protein and the pathogenesis of SCA2.