Recombinant Mouse Atxn2l Protein, Myc/DDK-tagged

• Cat.No.: Atxn2l-1784M
• Product Overview: Purified recombinant protein of mouse full-length ataxin 2-like (Atxn2l), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Involved in the regulation of stress granule and P-body formation.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 110.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Atxn2l ataxin 2-like [ Mus musculus (house mouse) ]
• Official Symbol: Atxn2l
• Synonyms: ATXN2L; ataxin 2-like; ataxin-2-like protein; ataxin 2 related protein; A2D; A2LG; A2RP; A2lp; Atxnl2
• Gene ID: 233871
• mRNA Refseq: NM_183020
• Protein Refseq: NP_898841
• UniProt ID: Q7TQH0

Reviews

04/03/2022

The stability of ATXN2L means that we can store it and use it at any time without fear of its inactivation or deterioration.

02/10/2020

ATXN2L significantly improved the reproducibility of Western blotting.

08/08/2019

The purity of ATXN2L is very high, which can ensure the safety of the experiment and also avoid unnecessary risks.

Q&As

How do ATXN2L protein abnormalities lead to neurological diseases?

At present, the relationship between ATXN2L protein and nervous system diseases is not fully understood. However, some studies have shown that the mutation or abnormal expression of ATXN2L protein may lead to the dysfunction of this protein in cells, thereby affecting the normal function of nerve cells.

How is the function of ATXN2L protein regulated?

The regulation of ATXN2L protein function involves multiple levels. For example, its expression levels can be influenced by transcription factors and RNA splicing regulation. In addition, it interacts with other proteins to form complexes involved in the regulation of cellular processes.

Which diseases or pathological processes are associated with ATXN2L protein?

Current studies have shown that ATXN2L protein is associated with multiple disease processes. For example, it is associated with neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease. In addition, ATXN2L protein may also be related to the occurrence and progression of malignant tumors such as breast cancer and lung cancer.

What are the biological functions of ATXN2L protein?

ATXN2L protein has multiple functions in cells. It is involved in the regulation of mRNA translation, RNA transport and cell adhesion, and may also play a role in the regulation of neural development and synaptic function.

What are the structural features of the ATXN2L protein?

It contains multiple conserved domains, the most prominent of which is RNA recognition motifs (RRMs). These domains may be related to their involvement in RNA recognition and binding functions.

In which tissues is ATXN2L protein highly expressed?

ATXN2L protein is expressed in several tissues, but its expression is higher in the nervous system. In addition, ATXN2L expression was also detected in liver, lung, heart and other tissues.

How is ATXN2L protein associated with ALS?

ATXN2L gene mutations have been found to be associated with ALS. Several specific ATXN2L mutations have been implicated in the pathogenesis of familial and sporadic ALS. These mutations may lead to the abnormal expression or function of ATXN2L protein, and then affect the normal function of nerve cells.