Recombinant Mouse BH3 Interacting Domain Death Agonist
Cat.No. : | Bid-1382M |
Product Overview : | Recombinant Mouse BID produced inE.Coliis a single, non-glycosylated polypeptide chain containing 1-195 amino acids and having a molecular mass of 22 kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | Bid-1382M |
Description : | BID is a pro-apoptotic Bcl-2 protein having only the BH3 domain. In reaction to apoptotic signaling, BID interacts with another Bcl-2 family of cell death regulators, called Bax, they form a heterodimer resulting to the insertion of Bax into the outer mitochondrial membrane. Bax induces the opening of the mitochondrial voltage-dependent anion channel which lead to the release of cytochrome c and other pro-apoptotic factors from the mitochondria resulting in activation of caspases. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8). CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. The major proteolytic product p15 BID releasea cytochrome c. Isoform 1, Isoform 2 and Isoform 4 induce ice-like proteases and apoptosis while Isoform 3 does not induce apoptosis. |
Source : | Escherichia Coli. |
Physical Appearance : | Sterile Filtered colorless liquid formulation. |
Formulation : | The Mouse BID protein solution contains 10mM Tris-HCL pH-8, 1mM EDTA and 250mM NaCl. |
Purity : | Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Stability : | BID although stable at 15°C for 1 week, should be stored desiccated below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
Gene Name : | Bid BH3 interacting domain death agonist [ Mus musculus ] |
Synonyms : | Bid; BH3 interacting domain death agonist; AI875481; AU022477; 2700049M22Rik; OTTMUSP00000028756 |
Gene ID : | 12122 |
mRNA Refseq : | NM_007544 |
Protein Refseq : | NP_031570 |
UniProt ID : | P70444 |
Chromosome Location : | 6 F1; 6 54.0 cM |
Pathway : | Alzheimer"s disease; Amyotrophic lateral sclerosis (ALS); Natural killer cell mediated cytotoxicity; Pathways in cancer; p53 signaling pathway |
Function : | protein binding |
Products Types
◆ Recombinant Protein | ||
Bid-711M | Recombinant Mouse Bid Protein, MYC/DDK-tagged | +Inquiry |
Bid-4029M | Active Recombinant Mouse Bid protein(Met1-Asp195), His&GST-tagged | +Inquiry |
BID-2006H | Recombinant Human BID Protein, His-tagged | +Inquiry |
BID-1032M | Recombinant Mouse BID Protein, His (Fc)-Avi-tagged | +Inquiry |
BID-26711TH | Recombinant Human BID | +Inquiry |
◆ Lysates | ||
BID-8455HCL | Recombinant Human BID 293 Cell Lysate | +Inquiry |
BID-8456HCL | Recombinant Human BID 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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