| Description : |
Predicted to enable antigen binding activity; protein domain specific binding activity; and ubiquitin protein ligase binding activity. Involved in B cell mediated immunity; CD40 signaling pathway; and cellular calcium ion homeostasis. Acts upstream of or within several processes, including defense response to other organism; positive regulation of B cell activation; and positive regulation of interleukin-12 production. Located in external side of plasma membrane and intracellular membrane-bounded organelle. Part of CD40 receptor complex. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); end stage renal disease; hyperimmunoglobulin syndrome (multiple); and non-Hodgkin lymphoma (multiple). Orthologous to human CD40 (CD40 molecule). |
| Source : |
HEK293 |
| Species : |
Mouse |
| Tag : |
Fc |
| Form : |
Lyophilized |
| Molecular Mass : |
44.9 kDa |
| Protein Length : |
289 |
| AA Sequence : |
MVSLPRLCALWGCLLTAVHLGQCVT CSDKQYLHDGQCCDLCQPGSRLTSH CTALEKTQCHPCDSGEFSAQWNREI RCHQHRHCEPNQGLRVKKEGTAESD TVCTCKEGQHCTSKDCEACAQHTPC IPGFGVMEMATETTDTVCHPCPVGF FSNQSSLFEKCYPWTSCEDKNLEVL QKGTSQTNVICGLKSRMRALLVIPV VMGILITIFGVFLYIKKVVKKPKDN EILPPAARRQDPQEMEDYPGHNTAA PVQETLHGCQPVTQEDGKESRISVQ ERQVTDSIALRPLV |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
