Recombinant Mouse Cfh protein, His-tagged

• Cat.No.: Cfh-392M
• Product Overview: Recombinant Mouse Cfh (Ser875-Val1252) fused with His tag at C-terminal was expressed in HEK293.

Specification

• Source: HEK293
• Species: Mouse
• Tag: His
• Predicted N Terminal: Ser 875
• Form: Lyophilized from sterile PBS, pH 7.4.1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.2. Please contact us for any concerns or special requirements.
• Molecular Mass: The recombinant mouse Cfh consists 389 amino acids and predicts a molecular mass of 43.8 kDa.
• Protein length: Ser875-Val1252
• Endotoxin: < 1.0 EU per μg protein as determined by the LAL method.
• Purity: > 90 % as determined by SDS-PAGE.
• Stability: Samples are stable for up to twelve months from date of receipt at -70 centigrade
• Storage: Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Gene Information

• Gene Name: Cfh complement component factor h [ Mus musculus ]
• Official Symbol: Cfh
• Synonyms: CFH; complement component factor h; complement factor H; protein beta-1-H; complement factor H related protein 3A4/5G4; NOM; Sas1; Mud-1; Sas-1
• Gene ID: 12628
• mRNA Refseq: NM_009888
• Protein Refseq: NP_034018
• UniProt ID: P06909
• Chromosome Location: 1 61.62 cM; 1 F
• Pathway: Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Staphylococcus aureus infection, organism-specific biosystem; Staphylococcus aureus infection, conserved biosystem
• Function: complement component C3b binding; eukaryotic cell surface binding; heparin binding

Reviews

11/16/2020

Exceptional protein expression optimization support, highly appreciated assistance.

07/31/2020

Precise protein quantification, ensures data accuracy in our research.

03/10/2018

Timely antibody validation, an invaluable asset for our laboratory.

Q&As

What is the impact of CFH mutations on the risk of developing atypical hemolytic uremic syndrome (aHUS)?

Mutations in CFH increase the risk of aHUS, affecting complement regulation and leading to kidney damage.

How does CFH (Complement Factor H) regulate the complement system and prevent overactivation?

CFH controls the complement system, preventing its overactivation and protecting against immune damage.

How does CFH influence the immune response to bacterial infections?

CFH modulates the immune response to bacterial infections, balancing defense mechanisms.

How does CFH deficiency contribute to the development of age-related macular degeneration (AMD)?

CFH deficiency is linked to AMD, due to impaired regulation of the complement pathway in the retina.

What role does CFH play in protecting host cells from complement-mediated damage?

CFH shields host cells from complement-mediated injury, maintaining tissue integrity.

What are the mechanisms by which CFH modulates inflammation and immune homeostasis?

CFH regulates inflammation and maintains immune balance, crucial for preventing excessive immune responses.

How do alterations in CFH expression or function affect renal function and the development of kidney diseases?

Changes in CFH function can impact kidney health, potentially leading to renal diseases due to altered complement activity.