Recombinant Mouse Ctsb Protein, His-tagged

• Cat.No.: Ctsb-7184M
• Product Overview: Recombinant Mouse Ctsb Protein with a His tag.

Specification

• Description: This gene encodes a member of the peptidase C1 family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to generate the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. Homozygous knockout mice for this gene exhibit reduced pancreatic damage following induced pancreatitis and reduced hepatocyte apoptosis in a model of liver injury. Pseudogenes of this gene have been identified in the genome.
• Species: Mouse
• Tag: His
• Form: Liquid
• Molecular Mass: 36.4 kDa
• Protein length: 18-339
• AA Sequence: HDKPSFHPLSDDLINYINKQNTTWQ AGRNFYNVDISYLKKLCGTVLGGPK LPGRVAFGEDIDLPETFDAREQWSN CPTIGQIRDQGSCGSCWAFGAVEAI SDRTCIHTNGRVNVEVSAEDLLTCC GIQCGDGCNGGYPSGAWSFWTKKGL VSGGVYNSHVGCLPYTIPPCEHHVN GSRPPCTGEGDTPRCNKSCEAGYSP SYKEDKHFGYTSYSVSNSVKEIMAE IYKNGPVEGAFTVFSDFLTYKSGVY KHEAGDMMGGHAIRILGWGVENGVP YWLAANSWNLDWGDNGFFKILRGEN HCGIESEIVAGIPRTDQYWGRFLEH HHHHH
• Endotoxin: < 1.0 EU/μg of protein (determined by LAL method)
• Purity: > 90 % by SDS-PAGE
• Stability: Shelf life: one year from despatch.
• Storage: Store undiluted at 2-8 centigrade for one week or (in aliquots) at -20 to -80 centigrade for longer. Avoid repeated freezing and thawing.
• Concentration: 0.5 mg/mL (determined by absorbance at 280nm)
• Storage Buffer: Phosphate Buffered Saline (pH 7.4) containing 10 % glycerol.

Gene Information

• Gene Name: Ctsb cathepsin B [ Mus musculus (house mouse) ]
• Official Symbol: Ctsb
• Synonyms: Ctsb; cathepsin B; CB; cathepsin B; cathepsin B1; EC 3.4.22.1
• Gene ID: 13030
• mRNA Refseq: NM_007798
• Protein Refseq: NP_031824
• UniProt ID: P10605