Recombinant Mouse Daxx Protein, Myc/DDK-tagged
Cat.No. : | Daxx-2458M |
Product Overview : | Purified recombinant protein of mouse full-length Fas death domain-associated protein (Daxx), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
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Description : | Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as histone chaperone that facilitates deposition of histone H3.3. Acts as targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 81.5 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Daxx Fas death domain-associated protein [ Mus musculus (house mouse) ] |
Official Symbol : | Daxx |
Synonyms : | DAXX; Fas death domain-associated protein; death domain-associated protein 6; death-domain associated protein; MGC150289 |
Gene ID : | 13163 |
mRNA Refseq : | NM_007829 |
Protein Refseq : | NP_031855 |
UniProt ID : | O35613 |
Products Types
◆ Recombinant Protein | ||
DAXX-2352H | Recombinant Human DAXX Protein, GST-tagged | +Inquiry |
DAXX-1182H | Recombinant Human DAXX Protein (1-233 aa), GST-tagged | +Inquiry |
DAXX-1315H | Recombinant Human DAXX Protein, His&GST-tagged | +Inquiry |
DAXX-418H | Recombinant Human DAXX Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
DAXX-717H | Recombinant Human DAXX Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
DAXX-7071HCL | Recombinant Human DAXX 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionDAXX protein interacts with a wide range of cellular proteins, including transcription factors, histones, and chromatin remodeling complexes, which has implications for its clinical relevance in various cellular processes.
Targeting DAXX protein may have therapeutic implications in cancer treatment, as well as in aging-related diseases and neurodegenerative disorders, by modulating its functions and interactions with other cellular proteins.
Studies have suggested that DAXX protein may have implications in aging-related diseases, particularly in relation to telomere dysfunction and cellular senescence.
DAXX protein has been implicated in neurodegenerative diseases through its involvement in cellular stress responses and protein aggregation, which are hallmarks of diseases such as Alzheimer's and Parkinson's.
DAXX protein has been identified as a potential therapeutic target for cancer treatment due to its involvement in regulating the activity of key oncogenes and tumor suppressor genes.
Customer Reviews (3)
Write a reviewIts ability to provide accurate and reliable results in this particular application makes it a preferred choice for researchers studying antigen-antibody interactions and immune responses.
The DAXX protein's sensitivity and specificity ensure precise measurements, contributing to the overall success of ELISA experiments.
the DAXX protein has proven to be invaluable in protein electron microscopy structure analysis.
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