Recombinant Mouse Ddrgk1 Protein, Myc/DDK-tagged
Cat.No. : | Ddrgk1-2497M |
Product Overview : | Purified recombinant protein of mouse full-length DDRGK domain containing 1 (Ddrgk1), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
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Description : | Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, which plays a key role in reticulophagy (also called ER-phagy). In response to endoplasmic reticulum stress, promotes recruitment of the E3 UFM1-protein ligase UFL1 to the endoplasmic reticulum membrane: in turn, UFL1 mediates ufmylation of proteins such as RPN1 and RPL26/uL24, promoting reticulophagy of endoplasmic reticulum sheets. Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) by regulating ERN1/IRE1-alpha stability. Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis or inflammatory response. Required for TRIP4 ufmylation, thereby regulating nuclear receptors-mediated transcription. May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B. Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 36 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Ddrgk1 DDRGK domain containing 1 [ Mus musculus (house mouse) ] |
Official Symbol : | Ddrgk1 |
Synonyms : | DDRGK1; DDRGK domain containing 1; DDRGK domain-containing protein 1; UFM1-binding protein 1 containing a PCI domain; Ufbp1; AI326138; RP23-100C5.9; 1110001I20Rik; 2600009E05Rik |
Gene ID : | 77006 |
mRNA Refseq : | NM_029832 |
Protein Refseq : | NP_084108 |
UniProt ID : | Q80WW9 |
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DDRGK1-1210R | Recombinant Rhesus monkey DDRGK1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
DDRGK1-7023HCL | Recombinant Human DDRGK1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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