Recombinant Mouse DHODH Protein

• Cat.No.: DHODH-09M
• Product Overview: Recombinant Mouse DHODH Protein was expressed in E. coli.

Specification

• Description: Enables dihydroorotase activity and dihydroorotate dehydrogenase activity. Involved in 'de novo' UMP biosynthetic process and UDP biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; branchial arch; limb bud; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (dihydroorotate dehydrogenase (quinone)).
• Source: E. coli
• Species: Mouse
• Form: Liquid. In 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.
• Molecular Mass: ~40 kDa
• AA Sequence: TGDDHFYAEYLMPALQRLLDPESAH RLAVRVISLGLLPRATFQDSNMLEV RVLGHKFRNPVGIAAGFDKHGEAVD GLYKLGFGFVEVGSVTPQPQEGNPR PRVFRLPEDQAVINRYGFNSHGLSA VEHRLRARQQKQTQLTTDGLPLGIN LGKNKTSVDAAADYVEGVRILGPLA DYLVVNVSSPNTAGLRSLQGKTELR RLLSKVLQERDALKGPQKPAVLVKI APDLTAQDKEDIASVARELGIDGLI ITNTTVSRPVGLQGALRSETGGLSG KPLRDLSTQTIREMYALTQGTIPII GVGGVSSGQDALEKIQAGASLVQLY TALTFLGPPVVARVKRELEALLKER GFNTVTDAIGVDHRR
• Purity: >90%
• Storage: Short Term Storage at 4 centigrade, Long Term, please prepare aliquots with 20% glycerol and store at -20 to -80 centigrade. Avoid freeze/thaw cycles.
• Concentration: 0.26 mg/ml
• Official Full Name: Dihydroorotate dehydrogenase

Gene Information

• Gene Name: Dhodh dihydroorotate dehydrogenase [ Mus musculus (house mouse) ]
• Official Symbol: DHODH
• Synonyms: AI834883; 2810417D19Rik
• Gene ID: 56749
• mRNA Refseq: NM_020046
• Protein Refseq: NP_064430
• UniProt ID: O35435

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Q&As

How does DHODH contribute to pyrimidine biosynthesis?

It catalyzes a key step in the pyrimidine biosynthesis pathway, converting dihydroorotate to orotate.

What is the primary role of DHODH in cellular metabolism?

DHODH, dihydroorotate dehydrogenase, is crucial for the de novo synthesis of pyrimidines, essential for DNA and RNA synthesis.

How does DHODH interact with other enzymes in the pyrimidine biosynthesis pathway?

DHODH collaborates with other enzymes in pyrimidine biosynthesis, playing a role in nucleotide metabolism.

What role does DHODH play in cell proliferation and growth?

DHODH is important for cell proliferation, as pyrimidine synthesis is essential for DNA replication and cell growth.

How do genetic variations in DHODH affect its function in nucleotide synthesis?

Genetic mutations in DHODH can disrupt nucleotide synthesis, affecting cellular replication and function.

What is the impact of altered DHODH activity on autoimmune diseases?

Altered DHODH activity is linked with autoimmune conditions, as it affects lymphocyte proliferation and function.

What potential therapeutic applications arise from targeting DHODH in disease treatment?

Targeting DHODH in therapies could be effective in treating autoimmune diseases and certain cancers by modulating pyrimidine synthesis.