Recombinant Mouse Disc1 Protein, Myc/DDK-tagged
Cat.No. : | Disc1-2571M |
Product Overview : | Purified recombinant protein of mouse full-length disrupted in schizophrenia 1 (Disc1), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
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Description : | Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding. Plays a role, together with PCNT, in the microtubule network formation. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 92.5 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Disc1 disrupted in schizophrenia 1 [ Mus musculus (house mouse) ] |
Official Symbol : | Disc1 |
Synonyms : | DISC1; disrupted in schizophrenia 1; disrupted in schizophrenia 1 homolog |
Gene ID : | 244667 |
mRNA Refseq : | NM_174854 |
Protein Refseq : | NP_777279 |
UniProt ID : | Q811T9 |
Products Types
◆ Recombinant Protein | ||
DISC1-470H | Recombinant Human DISC1 Protein, His-tagged | +Inquiry |
Disc1-472R | Recombinant Rat Disc1 Protein, His-tagged | +Inquiry |
DISC1-1531R | Recombinant Rat DISC1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Disc1-471M | Recombinant Mouse Disc1 Protein, His-tagged | +Inquiry |
DISC1-766H | Recombinant Human DISC1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
DISC1-6918HCL | Recombinant Human DISC1 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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