Recombinant Mouse Dsg2 protein, His-tagged
Cat.No. : | Dsg2-40M |
Product Overview : | Recombinant Mouse Dsg2 protein(O55111)(Ala55-Ala618) is expressed from HEK293 with His tag at the C-terminal. |
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Source : | HEK293 |
Species : | Mouse |
Tag : | His |
Form : | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Molecular Mass : | The protein has a predicted MW of 63.7 kDa. Due to glycosylation, the protein migrates to 75-80 kDa based on Tris-Bis PAGE result. |
Protein Length : | Ala55-Ala618 |
Endotoxin : | Less than 1EU per μg by the LAL method. |
Purity : | > 95% as determined by Tris-Bis PAGE > 95% as determined by HPLC |
Storage : | -20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please avoid freeze-thaw cycles. |
Reconstitution : | Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Gene Name : | Dsg2 desmoglein 2 [ Mus musculus (house mouse) ] |
Official Symbol : | Dsg2 |
Synonyms : | DSG2; desmoglein 2; desmoglein-2; CDHF5; HDGC; cadherin family member 5; ARVC10; ARVD10; CMD1BB; MGC117034; MGC117036; MGC117037 |
Gene ID : | 13511 |
mRNA Refseq : | NM_007883 |
Protein Refseq : | NP_031909 |
UniProt ID : | O55111 |
Products Types
◆ Recombinant Protein | ||
DSG2-181H | Recombinant Human DSG2 Protein, His (Fc)-Avi-tagged | +Inquiry |
DSG2-2868H | Recombinant Human DSG2 protein(741-900 aa), C-His-tagged | +Inquiry |
Dsg2-56M | Recombinant Mouse Dsg2 Protein | +Inquiry |
DSG2-4100H | Recombinant Human DSG2 protein(50-609aa), His-tagged | +Inquiry |
DSG2-400H | Recombinant Human DSG2 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
DSG2-6807HCL | Recombinant Human DSG2 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionDesmoglein-2 plays a role in wound healing and tissue repair by facilitating cell adhesion and migration. Manipulating its activity may have therapeutic implications for enhancing these processes.
Desmoglein-2 expression is regulated at transcriptional and post-translational levels. Dysregulation is linked to autoimmune diseases like pemphigus, where autoantibodies target Desmoglein-2, leading to skin blistering.
Desmoglein-2 has a unique molecular structure with extracellular domains facilitating cell-cell adhesion. It interacts with other desmosomal components, such as Desmocollins and Plakoglobin, forming strong intercellular junctions.
Desmoglein-2 participates in cell signaling, impacting pathways involved in cell adhesion, migration, and survival. Its interactions with other desmosomal components modulate signaling cascades essential for cellular function.
Desmoglein-2 influences EMT, a process crucial for cancer invasion and metastasis. Changes in Desmoglein-2 expression and localization contribute to alterations in cell adhesion dynamics during EMT.
Customer Reviews (3)
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